Complete response to capecitabine in a frail, elderly patient with metastatic colorectal cancer: A case report

Morena Fasano, Alessio Fabozzi, Guido Giordano, Filippo Venturini, Gaetano Aurilio, Flavia Cantile, Teresa Fabozzi, Vincenzo Ricci, Giuseppe Santabarbara, Floriana Morgillo, Fortunato Ciardiello, Ferdinando De Vita

Research output: Contribution to journalArticlepeer-review


The clinical management of frail, elderly patients affected by colorectal cancer (CRC) remains a subject of debate. The present study reports the case of an elderly man with metastatic CRC (mCRC) who was successfully treated with capecitabine. The patient survived for 29 months, thus highlighting its potential activity in terms of obtaining a complete response and high efficacy. A 77-year-old man presented with adenocarcinoma of the rectum with multiple and synchronous liver metastases, in addition to several comorbidities. The patient received single‑agent capecitabine chemotherapy (825 mg/mq twice a day) on days 1-14 of a 21-day cycle. Following 12 cycles of well-tolerated therapy, a computed tomography scan revealed a complete response with no evidence of liver metastases. An overall survival of 29 months was documented, and the patient eventually succumbed to a diabetes-related complication. In compromised patients with mCRC, reduced-dose capecitabine is an excellent therapeutic option due to its positive safety profile, activity and efficacy.

Original languageEnglish
Pages (from-to)979-983
Number of pages5
JournalOncology Letters
Issue number2
Publication statusPublished - Feb 1 2017


  • Advanced disease
  • Capecitabine
  • Colorectal cancer
  • Complete response
  • Frail elderly patient

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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