Complete response to second line paclitaxel every 2 weeks of eyelid kaposi sarcoma: A case report

Anna Elisabetta Brunetti, Attilio Guarini, Vito Lorusso, Carla Minoia, Angela Sabatelli, Ilaria Marech, Nicola Silvestris

Research output: Contribution to journalArticle

Abstract

A 77-year-old male patient presented to our attention with violaceous nodular lesions on the skin of his hands and lower extremities. Clinical and histologic examination supported the diagnosis of Kaposi sarcoma. A first-line systemic chemotherapy based on liposomal doxorubicin at a dosage of 40 mg/mevery 3 weeks for 5 cycles was carried out, resulting in partial resolution of skin lesions. However, 1 year later, a relapse of the disease in the lower limbs and a new lesion of the left eyelid were found, therefore the patient began a second-line therapy with 100 mg/mpaclitaxel every 2 weeks. After 8 cycles of therapy, we observed a complete remission of eyelid tumor and a partial response of lower limbs lesions up to 6 months of follow up. In conclusion, eyelid Kaposi sarcoma was successfully treated with paclitaxel every 2 weeks, obtaining a complete response.

Original languageEnglish
JournalOphthalmic Plastic and Reconstructive Surgery
Volume29
Issue number5
DOIs
Publication statusPublished - Sep 2013

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Kaposi's Sarcoma
Eyelids
Paclitaxel
Lower Extremity
Skin
Hand
Recurrence
Drug Therapy
Therapeutics
Neoplasms

ASJC Scopus subject areas

  • Ophthalmology
  • Surgery

Cite this

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title = "Complete response to second line paclitaxel every 2 weeks of eyelid kaposi sarcoma: A case report",
abstract = "A 77-year-old male patient presented to our attention with violaceous nodular lesions on the skin of his hands and lower extremities. Clinical and histologic examination supported the diagnosis of Kaposi sarcoma. A first-line systemic chemotherapy based on liposomal doxorubicin at a dosage of 40 mg/mevery 3 weeks for 5 cycles was carried out, resulting in partial resolution of skin lesions. However, 1 year later, a relapse of the disease in the lower limbs and a new lesion of the left eyelid were found, therefore the patient began a second-line therapy with 100 mg/mpaclitaxel every 2 weeks. After 8 cycles of therapy, we observed a complete remission of eyelid tumor and a partial response of lower limbs lesions up to 6 months of follow up. In conclusion, eyelid Kaposi sarcoma was successfully treated with paclitaxel every 2 weeks, obtaining a complete response.",
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T1 - Complete response to second line paclitaxel every 2 weeks of eyelid kaposi sarcoma

T2 - A case report

AU - Brunetti, Anna Elisabetta

AU - Guarini, Attilio

AU - Lorusso, Vito

AU - Minoia, Carla

AU - Sabatelli, Angela

AU - Marech, Ilaria

AU - Silvestris, Nicola

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