Complete Sequencing of the HLA-A*68020102 Novel Allele Identified in Two Caucasoid Families

Elena Longhi, Sara Frison, Emanuela Andreini, Simone Haworth, Alberto Malagoli, Graziella Carella, Loretta Crespiatico, Francesca Poli, Mario Scalamogna

Research output: Contribution to journalArticlepeer-review

Abstract

We describe here the isolation and the full-length sequence of the coding region of the HLA new variant at the HLA-A locus officially named A*68020102. This variant shows an 11 base pairs deletion within the 5′ UTR region. The exon sequence is identical to that of A*6802 and the commercially available anti-A68 typing sera react with the antigen coded by the allele A*68020102. This variant was originally identified in two unrelated Caucasoid families because of discrepant HLA typing results between serology, Sequence Specific Oligonucleotide Probe (SSOP), and SBT. In fact, the A68 assigned by serology was undetectable with the molecular techniques. This has occurred because the deletion present in A*68020102 prevents specific amplification of HLA-A locus by some commercially available typing kits.

Original languageEnglish
Pages (from-to)206-210
Number of pages5
JournalHuman Immunology
Volume68
Issue number3
DOIs
Publication statusPublished - Mar 2007

Keywords

  • 5′ UTR region
  • deletion
  • full length HLA-A gene
  • HLA-A*68
  • SBT

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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