Complex dynamics in the granual layer of the cerebellum: Large-scale computational reconstructions

Egidio D'Angelo, Sergio Solinas, Eduardo Ros, Jesus Garrido, Henrik Jörntell, Patrick Van Der Smagt

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Realistic modeling of the cerebellum granular layer has remained an unresolved issue. Now the availability of detailed single neuron codes and of a wealth of experimental results on single cell and network functions in vitro and in vivo has allowed reconsidering the issue. We have constructed a detailed computational model of the cerebellum granular layer and mapped it against several cellular and network constraints including: 1) center-surround organization 2) time-windowing 3) non-linear filtering 4) theta-frequency oscillations the model, purely based on microscopic properties (connectivity and single-neuron functions) has been able to reproduce these four higher-level effects. Therefore, the granular layer model is proving a powerful tool for predicting cerebellar computations.

Original languageEnglish
Title of host publication4th International Conference on Cognitive Systems, CogSys 2010
Publication statusPublished - 2010
Event4th International Conference on Cognitive Systems, CogSys 2010 - Zurich, Switzerland
Duration: Jan 27 2010Jan 28 2010

Other

Other4th International Conference on Cognitive Systems, CogSys 2010
CountrySwitzerland
CityZurich
Period1/27/101/28/10

ASJC Scopus subject areas

  • Artificial Intelligence
  • Information Systems

Fingerprint Dive into the research topics of 'Complex dynamics in the granual layer of the cerebellum: Large-scale computational reconstructions'. Together they form a unique fingerprint.

Cite this