Complex karyotype newly defined: The strongest prognostic factor in advanced childhood myelodysplastic syndrome

Gudrun Göhring, Kyra Michalova, H. Berna Beverloo, David Betts, Jochen Harbott, Oskar A. Haas, Gitte Kerndrup, Laura Sainati, Eva Bergstraesser, Henrik Hasle, Jan Starý, Monika Trebo, Marry M. Van Den Heuvel-Eibrink, Marco Zecca, Elisabeth R. Van Wering, Alexandra Fischer, Peter Noellke, Brigitte Strahm, Franco Locatelli, Charlotte M. NiemeyerBrigitte Schlegelberger

Research output: Contribution to journalArticlepeer-review

Abstract

To identify cytogenetic risk factors predicting outcome in children with advanced myelodysplastic syndrome, overall survival of 192 children prospectively enrolled in European Working Group of Myelodysplastic Syndrome in Childhood studies was evaluated with regard to karyotypic complexity. Structurally complex constitutes a new definition of complex karyotype characterized by more than or equal to 3 chromosomal aberrations, including at least one structural aberration. Five-year overall survival in patients with more than or equal to 3 clonal aberrations, which were not structurally complex, did not differ from that observed in patients with normal karyotype. Cox regression analysis revealed the presence of a monosomal and structurally complex karyotype to be strongly associated with poor prognosis (hazard ratio = 4.6, P <.01). Notably, a structurally complex karyotype without a monosomy was associated with a very short 2-year overall survival probability of only 14% (hazard ratio = 14.5; P <.01). The presence of a structurally complex karyotype was the strongest independent prognostic marker predicting poor outcome in children with advanced myelodysplastic syndrome.

Original languageEnglish
Pages (from-to)3766-3769
Number of pages4
JournalBlood
Volume116
Issue number19
DOIs
Publication statusPublished - Nov 11 2010

ASJC Scopus subject areas

  • Hematology
  • Biochemistry
  • Cell Biology
  • Immunology

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