Complex segregation analysis for obsessive compulsive disorder and related disorders

Maria Cristina Cavallini, Lorenza Pasquale, Laura Bellodi, Enrico Smeraldi

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Complex segregation analysis was applied to a sample of 107 Italian families with probands with obsessive compulsive disorder (OCD), using regressive logistic models to test for possible models of genetic transmission. We used two different phenotypic definitions of affection: 1) OCD; and 2) OCD plus Tourette's syndrome/chronic motor tics (CMT). Because of the potential relationship between OCD, Tourette's syndrome (TS), and other tic disorders, we considered these diagnoses to be determined by the same liability in subsequent steps of the analysis. For the 107 OCD families, the best fit was a dominant model of transmission (with a higher penetrance for females). When the phenotype boundaries were widened (OCD + CMT + TS), an unrestricted model of transmission became the best fit. We concluded that additional data are needed to support the hypothesis that Tourette's syndrome and OCD share a common etiology: on the basis of clinical and epidemiological considerations, the OCD phenotype probably presents a higher level of heterogeneity than the TS phenotype, and it could be regulated through different etiologic pathways.

Original languageEnglish
Pages (from-to)38-43
Number of pages6
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume88
Issue number1
DOIs
Publication statusPublished - Feb 5 1999

Fingerprint

Obsessive-Compulsive Disorder
Tourette Syndrome
Phenotype
Tic Disorders
Penetrance
Genetic Models
Logistic Models

Keywords

  • Obsessive compulsive disorder
  • Regressive logistic models
  • Segregation analysis
  • Tourette's syndrome

ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)

Cite this

Complex segregation analysis for obsessive compulsive disorder and related disorders. / Cavallini, Maria Cristina; Pasquale, Lorenza; Bellodi, Laura; Smeraldi, Enrico.

In: American Journal of Medical Genetics - Neuropsychiatric Genetics, Vol. 88, No. 1, 05.02.1999, p. 38-43.

Research output: Contribution to journalArticle

Cavallini, Maria Cristina ; Pasquale, Lorenza ; Bellodi, Laura ; Smeraldi, Enrico. / Complex segregation analysis for obsessive compulsive disorder and related disorders. In: American Journal of Medical Genetics - Neuropsychiatric Genetics. 1999 ; Vol. 88, No. 1. pp. 38-43.
@article{4bafe98bbfa4477d91f7290aa44902e4,
title = "Complex segregation analysis for obsessive compulsive disorder and related disorders",
abstract = "Complex segregation analysis was applied to a sample of 107 Italian families with probands with obsessive compulsive disorder (OCD), using regressive logistic models to test for possible models of genetic transmission. We used two different phenotypic definitions of affection: 1) OCD; and 2) OCD plus Tourette's syndrome/chronic motor tics (CMT). Because of the potential relationship between OCD, Tourette's syndrome (TS), and other tic disorders, we considered these diagnoses to be determined by the same liability in subsequent steps of the analysis. For the 107 OCD families, the best fit was a dominant model of transmission (with a higher penetrance for females). When the phenotype boundaries were widened (OCD + CMT + TS), an unrestricted model of transmission became the best fit. We concluded that additional data are needed to support the hypothesis that Tourette's syndrome and OCD share a common etiology: on the basis of clinical and epidemiological considerations, the OCD phenotype probably presents a higher level of heterogeneity than the TS phenotype, and it could be regulated through different etiologic pathways.",
keywords = "Obsessive compulsive disorder, Regressive logistic models, Segregation analysis, Tourette's syndrome",
author = "Cavallini, {Maria Cristina} and Lorenza Pasquale and Laura Bellodi and Enrico Smeraldi",
year = "1999",
month = "2",
day = "5",
doi = "10.1002/(SICI)1096-8628(19990205)88:1<38::AID-AJMG7>3.0.CO;2-#",
language = "English",
volume = "88",
pages = "38--43",
journal = "American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics",
issn = "1552-4841",
publisher = "wiley",
number = "1",

}

TY - JOUR

T1 - Complex segregation analysis for obsessive compulsive disorder and related disorders

AU - Cavallini, Maria Cristina

AU - Pasquale, Lorenza

AU - Bellodi, Laura

AU - Smeraldi, Enrico

PY - 1999/2/5

Y1 - 1999/2/5

N2 - Complex segregation analysis was applied to a sample of 107 Italian families with probands with obsessive compulsive disorder (OCD), using regressive logistic models to test for possible models of genetic transmission. We used two different phenotypic definitions of affection: 1) OCD; and 2) OCD plus Tourette's syndrome/chronic motor tics (CMT). Because of the potential relationship between OCD, Tourette's syndrome (TS), and other tic disorders, we considered these diagnoses to be determined by the same liability in subsequent steps of the analysis. For the 107 OCD families, the best fit was a dominant model of transmission (with a higher penetrance for females). When the phenotype boundaries were widened (OCD + CMT + TS), an unrestricted model of transmission became the best fit. We concluded that additional data are needed to support the hypothesis that Tourette's syndrome and OCD share a common etiology: on the basis of clinical and epidemiological considerations, the OCD phenotype probably presents a higher level of heterogeneity than the TS phenotype, and it could be regulated through different etiologic pathways.

AB - Complex segregation analysis was applied to a sample of 107 Italian families with probands with obsessive compulsive disorder (OCD), using regressive logistic models to test for possible models of genetic transmission. We used two different phenotypic definitions of affection: 1) OCD; and 2) OCD plus Tourette's syndrome/chronic motor tics (CMT). Because of the potential relationship between OCD, Tourette's syndrome (TS), and other tic disorders, we considered these diagnoses to be determined by the same liability in subsequent steps of the analysis. For the 107 OCD families, the best fit was a dominant model of transmission (with a higher penetrance for females). When the phenotype boundaries were widened (OCD + CMT + TS), an unrestricted model of transmission became the best fit. We concluded that additional data are needed to support the hypothesis that Tourette's syndrome and OCD share a common etiology: on the basis of clinical and epidemiological considerations, the OCD phenotype probably presents a higher level of heterogeneity than the TS phenotype, and it could be regulated through different etiologic pathways.

KW - Obsessive compulsive disorder

KW - Regressive logistic models

KW - Segregation analysis

KW - Tourette's syndrome

UR - http://www.scopus.com/inward/record.url?scp=0033525022&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033525022&partnerID=8YFLogxK

U2 - 10.1002/(SICI)1096-8628(19990205)88:1<38::AID-AJMG7>3.0.CO;2-#

DO - 10.1002/(SICI)1096-8628(19990205)88:1<38::AID-AJMG7>3.0.CO;2-#

M3 - Article

C2 - 10050965

AN - SCOPUS:0033525022

VL - 88

SP - 38

EP - 43

JO - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

JF - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

SN - 1552-4841

IS - 1

ER -