Complex splicing in the human T-cell leukemia virus (HTLV) family of retroviruses

Novel mRNAs and proteins produced by HTLV type I

V. Ciminale, G. N. Pavlakis, D. Derse, C. P. Cunningham, B. K. Felber

Research output: Contribution to journalArticle

175 Citations (Scopus)

Abstract

Novel cytoplasmic mRNA species produced by human T-cell leukemia virus type I (HTLV-I) were cloned by using the polymerase chain reaction technique. Five novel 3' splice sites located in the X region and upstream of the env gene were identified. Splicing to the 3' splice sites in the X region generates mRNAs that express two previously unidentified viral proteins, named Rof and Tof. Tof accumulates in the nucleoli of transfected cells. The other viruses of the HTLV family, such as HTLV-II and bovine leukemia virus, also have a complex splicing pattern and are capable of producing additional proteins encoded in the X region. These results suggest that HTLV-I and other members of the HTLV family produce novel proteins, which may contribute to the biological properties of these viruses.

Original languageEnglish
Pages (from-to)1737-1745
Number of pages9
JournalJournal of Virology
Volume66
Issue number3
Publication statusPublished - 1992

Fingerprint

Primate T-lymphotropic virus 1
Retroviridae
Deltaretrovirus
RNA Splice Sites
Human T-lymphotropic virus 1
Cell Nucleolus
Human T-lymphotropic virus 2
Bovine Leukemia Virus
Viruses
env Genes
Messenger RNA
Viral Proteins
Proteins
proteins
Polymerase Chain Reaction
Bovine leukemia virus
viruses
viral proteins
cell nucleolus
polymerase chain reaction

ASJC Scopus subject areas

  • Immunology

Cite this

Complex splicing in the human T-cell leukemia virus (HTLV) family of retroviruses : Novel mRNAs and proteins produced by HTLV type I. / Ciminale, V.; Pavlakis, G. N.; Derse, D.; Cunningham, C. P.; Felber, B. K.

In: Journal of Virology, Vol. 66, No. 3, 1992, p. 1737-1745.

Research output: Contribution to journalArticle

Ciminale, V. ; Pavlakis, G. N. ; Derse, D. ; Cunningham, C. P. ; Felber, B. K. / Complex splicing in the human T-cell leukemia virus (HTLV) family of retroviruses : Novel mRNAs and proteins produced by HTLV type I. In: Journal of Virology. 1992 ; Vol. 66, No. 3. pp. 1737-1745.
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