Description of morphology, pathophysiology and clinical aspects of an unusual case of interstitial nephritis in a patient with pulmonary megamycetoma. The nephropathy was characterized by marked loss of sodium, mixed type of tubular acidosis, with lowered threshold of Tm and bicarbonate, reduced urinary acidification, and lack of response to acetazolamide. The abnormality of the proximal tubules was confirmed by the typical tubular proteinuria with the presence of lysozyme and B 2 microglobulin, and the distal lesion by the reduced urinary concentration and incapacity to lower the pH of the urine in conditions of systemic acidosis. Renal biopsy showed marked interstitial granulomatous infiltration with a few giant cells, tubular atrophy and normal glomeruli. Steroids were given for about a year. After 13 mth evaluation of tubular function showed that there was an improvement in kidney function.
|Translated title of the contribution||Complex tubulopathy in a case of granulomatous interstitial nephritis. Effects of steroid therapy|
|Number of pages||6|
|Publication status||Published - 1974|
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