Abstract
Description of morphology, pathophysiology and clinical aspects of an unusual case of interstitial nephritis in a patient with pulmonary megamycetoma. The nephropathy was characterized by marked loss of sodium, mixed type of tubular acidosis, with lowered threshold of Tm and bicarbonate, reduced urinary acidification, and lack of response to acetazolamide. The abnormality of the proximal tubules was confirmed by the typical tubular proteinuria with the presence of lysozyme and B 2 microglobulin, and the distal lesion by the reduced urinary concentration and incapacity to lower the pH of the urine in conditions of systemic acidosis. Renal biopsy showed marked interstitial granulomatous infiltration with a few giant cells, tubular atrophy and normal glomeruli. Steroids were given for about a year. After 13 mth evaluation of tubular function showed that there was an improvement in kidney function.
| Original language | Italian |
|---|---|
| Pages (from-to) | 222-227 |
| Number of pages | 6 |
| Journal | Minerva Nefrologica |
| Volume | 21 |
| Issue number | 3 |
| Publication status | Published - 1974 |
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ASJC Scopus subject areas
- Medicine(all)
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TUBULOPATIA COMPLESSA IN UN CASO DI NEFRITE INTERSTIZIALE GRANULOMATOSA. EFFETTI DELLA TERAPIA STEROIDEA. / de Vecchi, A.; Graziani, G.; Imbasciati, E.; Brancaccio, D.; Rivolta, E.
In: Minerva Nefrologica, Vol. 21, No. 3, 1974, p. 222-227.Research output: Contribution to journal › Article
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TY - JOUR
T1 - TUBULOPATIA COMPLESSA IN UN CASO DI NEFRITE INTERSTIZIALE GRANULOMATOSA. EFFETTI DELLA TERAPIA STEROIDEA
AU - de Vecchi, A.
AU - Graziani, G.
AU - Imbasciati, E.
AU - Brancaccio, D.
AU - Rivolta, E.
PY - 1974
Y1 - 1974
N2 - Description of morphology, pathophysiology and clinical aspects of an unusual case of interstitial nephritis in a patient with pulmonary megamycetoma. The nephropathy was characterized by marked loss of sodium, mixed type of tubular acidosis, with lowered threshold of Tm and bicarbonate, reduced urinary acidification, and lack of response to acetazolamide. The abnormality of the proximal tubules was confirmed by the typical tubular proteinuria with the presence of lysozyme and B 2 microglobulin, and the distal lesion by the reduced urinary concentration and incapacity to lower the pH of the urine in conditions of systemic acidosis. Renal biopsy showed marked interstitial granulomatous infiltration with a few giant cells, tubular atrophy and normal glomeruli. Steroids were given for about a year. After 13 mth evaluation of tubular function showed that there was an improvement in kidney function.
AB - Description of morphology, pathophysiology and clinical aspects of an unusual case of interstitial nephritis in a patient with pulmonary megamycetoma. The nephropathy was characterized by marked loss of sodium, mixed type of tubular acidosis, with lowered threshold of Tm and bicarbonate, reduced urinary acidification, and lack of response to acetazolamide. The abnormality of the proximal tubules was confirmed by the typical tubular proteinuria with the presence of lysozyme and B 2 microglobulin, and the distal lesion by the reduced urinary concentration and incapacity to lower the pH of the urine in conditions of systemic acidosis. Renal biopsy showed marked interstitial granulomatous infiltration with a few giant cells, tubular atrophy and normal glomeruli. Steroids were given for about a year. After 13 mth evaluation of tubular function showed that there was an improvement in kidney function.
UR - http://www.scopus.com/inward/record.url?scp=0016218263&partnerID=8YFLogxK
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M3 - Articolo
C2 - 4463300
AN - SCOPUS:0016218263
VL - 21
SP - 222
EP - 227
JO - Minerva Nefrologica
JF - Minerva Nefrologica
SN - 0026-4873
IS - 3
ER -