TUBULOPATIA COMPLESSA IN UN CASO DI NEFRITE INTERSTIZIALE GRANULOMATOSA. EFFETTI DELLA TERAPIA STEROIDEA

Translated title of the contribution: Complex tubulopathy in a case of granulomatous interstitial nephritis. Effects of steroid therapy

A. de Vecchi, G. Graziani, E. Imbasciati, D. Brancaccio, E. Rivolta

Research output: Contribution to journalArticle

Abstract

Description of morphology, pathophysiology and clinical aspects of an unusual case of interstitial nephritis in a patient with pulmonary megamycetoma. The nephropathy was characterized by marked loss of sodium, mixed type of tubular acidosis, with lowered threshold of Tm and bicarbonate, reduced urinary acidification, and lack of response to acetazolamide. The abnormality of the proximal tubules was confirmed by the typical tubular proteinuria with the presence of lysozyme and B 2 microglobulin, and the distal lesion by the reduced urinary concentration and incapacity to lower the pH of the urine in conditions of systemic acidosis. Renal biopsy showed marked interstitial granulomatous infiltration with a few giant cells, tubular atrophy and normal glomeruli. Steroids were given for about a year. After 13 mth evaluation of tubular function showed that there was an improvement in kidney function.

Original languageItalian
Pages (from-to)222-227
Number of pages6
JournalMinerva Nefrologica
Volume21
Issue number3
Publication statusPublished - 1974

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Interstitial Nephritis
Acidosis
Steroids
Kidney
Acetazolamide
Giant Cells
Muramidase
Bicarbonates
Proteinuria
Atrophy
Sodium
Urine
Biopsy
Lung
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

TUBULOPATIA COMPLESSA IN UN CASO DI NEFRITE INTERSTIZIALE GRANULOMATOSA. EFFETTI DELLA TERAPIA STEROIDEA. / de Vecchi, A.; Graziani, G.; Imbasciati, E.; Brancaccio, D.; Rivolta, E.

In: Minerva Nefrologica, Vol. 21, No. 3, 1974, p. 222-227.

Research output: Contribution to journalArticle

de Vecchi, A, Graziani, G, Imbasciati, E, Brancaccio, D & Rivolta, E 1974, 'TUBULOPATIA COMPLESSA IN UN CASO DI NEFRITE INTERSTIZIALE GRANULOMATOSA. EFFETTI DELLA TERAPIA STEROIDEA', Minerva Nefrologica, vol. 21, no. 3, pp. 222-227.
de Vecchi, A. ; Graziani, G. ; Imbasciati, E. ; Brancaccio, D. ; Rivolta, E. / TUBULOPATIA COMPLESSA IN UN CASO DI NEFRITE INTERSTIZIALE GRANULOMATOSA. EFFETTI DELLA TERAPIA STEROIDEA. In: Minerva Nefrologica. 1974 ; Vol. 21, No. 3. pp. 222-227.
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