Complexity and dynamics of HIV-1 quasispecies

S. Menzo, P. Bagnarelli, A. Monachetti, L. Fiorelli, M. Clementi

Research output: Contribution to journalArticle


The human immunodeficiency virus type 1 (HIV-1) envelope glycoproteins mediate virus entry into target cells by binding receptors of the cell membrane and fusing viral and cellular structures. In particular, recent crystallographic studies have clarified the complex role of the glycoprotein gp120 in the early phase of the infection. In this context the inter- and intra-host variability of the HIV-1 gp120 poses a major problem for the development of effective methods of immunization against this virus. In the present report, the relevant aspects emerging from the study of HIV-1 variability are addressed and several methodological approaches to evaluate HIV-1 diversity discussed.

Original languageEnglish
Pages (from-to)4-6
Number of pages3
JournalJournal of Biological Regulators and Homeostatic Agents
Issue number1
Publication statusPublished - 2000


  • Disease progression
  • HIV diversity evolution
  • Selective pressure

ASJC Scopus subject areas

  • Immunology
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Physiology (medical)
  • Medicine (miscellaneous)
  • Physiology
  • Agricultural and Biological Sciences(all)

Fingerprint Dive into the research topics of 'Complexity and dynamics of HIV-1 quasispecies'. Together they form a unique fingerprint.

  • Cite this

    Menzo, S., Bagnarelli, P., Monachetti, A., Fiorelli, L., & Clementi, M. (2000). Complexity and dynamics of HIV-1 quasispecies. Journal of Biological Regulators and Homeostatic Agents, 14(1), 4-6.