Complexity in influenza virus targeted drug design: Interaction with human sialidases

Leonard M G Chavas, Ryuichi Kato, Nobuhiro Suzuki, Mark Von Itzstein, Maretta C. Mann, Robin J. Thomson, Jeffrey C. Dyason, Jennifer McKimm-Breschkin, Paola Fusi, Cristina Tringali, Bruno Venerando, Guido Tettamanti, Eugenio Monti, Soichi Wakatsuki

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

With the global spread of the pandemic H1N1 and the ongoing pandemic potential of the H5N1 subtype, the influenza virus represents one of the most alarming viruses spreading worldwide. The influenza virus sialidase is an effective drug target, and a number of inhibitors are clinically effective against the virus (zanamivir, oseltamivir, peramivir). Here we report structural and biochemical studies of the human cytosolic sialidase Neu2 with influenza virus sialidase-targeting drugs and related compounds.

Original languageEnglish
Pages (from-to)2998-3002
Number of pages5
JournalJournal of Medicinal Chemistry
Volume53
Issue number7
DOIs
Publication statusPublished - Apr 8 2010

Fingerprint

Drug Design
Neuraminidase
Orthomyxoviridae
Drug Interactions
Pandemics
Zanamivir
Viruses
Oseltamivir
Drug Delivery Systems
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

Cite this

Chavas, L. M. G., Kato, R., Suzuki, N., Von Itzstein, M., Mann, M. C., Thomson, R. J., ... Wakatsuki, S. (2010). Complexity in influenza virus targeted drug design: Interaction with human sialidases. Journal of Medicinal Chemistry, 53(7), 2998-3002. https://doi.org/10.1021/jm100078r

Complexity in influenza virus targeted drug design : Interaction with human sialidases. / Chavas, Leonard M G; Kato, Ryuichi; Suzuki, Nobuhiro; Von Itzstein, Mark; Mann, Maretta C.; Thomson, Robin J.; Dyason, Jeffrey C.; McKimm-Breschkin, Jennifer; Fusi, Paola; Tringali, Cristina; Venerando, Bruno; Tettamanti, Guido; Monti, Eugenio; Wakatsuki, Soichi.

In: Journal of Medicinal Chemistry, Vol. 53, No. 7, 08.04.2010, p. 2998-3002.

Research output: Contribution to journalArticle

Chavas, LMG, Kato, R, Suzuki, N, Von Itzstein, M, Mann, MC, Thomson, RJ, Dyason, JC, McKimm-Breschkin, J, Fusi, P, Tringali, C, Venerando, B, Tettamanti, G, Monti, E & Wakatsuki, S 2010, 'Complexity in influenza virus targeted drug design: Interaction with human sialidases', Journal of Medicinal Chemistry, vol. 53, no. 7, pp. 2998-3002. https://doi.org/10.1021/jm100078r
Chavas LMG, Kato R, Suzuki N, Von Itzstein M, Mann MC, Thomson RJ et al. Complexity in influenza virus targeted drug design: Interaction with human sialidases. Journal of Medicinal Chemistry. 2010 Apr 8;53(7):2998-3002. https://doi.org/10.1021/jm100078r
Chavas, Leonard M G ; Kato, Ryuichi ; Suzuki, Nobuhiro ; Von Itzstein, Mark ; Mann, Maretta C. ; Thomson, Robin J. ; Dyason, Jeffrey C. ; McKimm-Breschkin, Jennifer ; Fusi, Paola ; Tringali, Cristina ; Venerando, Bruno ; Tettamanti, Guido ; Monti, Eugenio ; Wakatsuki, Soichi. / Complexity in influenza virus targeted drug design : Interaction with human sialidases. In: Journal of Medicinal Chemistry. 2010 ; Vol. 53, No. 7. pp. 2998-3002.
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