Complexity in the tumour microenvironment: Cancer associated fibroblast gene expression patterns identify both common and unique features of tumour-stroma crosstalk across cancer types

Paolo Gandellini, Francesca Andriani, Giuseppe Merlino, Francesca D'Aiuto, Luca Roz, Maurizio Callari

Research output: Contribution to journalArticle

Abstract

Cancer is a complex disease, driven by the accumulation of several somatic aberrations but fostered by a two-way interaction between tumour cells and the surrounding microenvironment. Cancer associated fibroblasts (CAFs) represent one of the major players in tumour-stroma crosstalk. Recent in vitro and in vivo studies, often conducted by employing high throughput approaches, have started unravelling the key pathways involved in their functional effects. This review focus on open challenges in the study of CAF properties and function, highlighting at the same time the existence of common mechanisms as well as peculiarities in different cancer types (breast, prostate and lung cancer). Although still limited by current experimental models, which are unable to deal with the full level of complexity of the tumour microenvironment, a better understanding of these mechanisms may enable the identification of new biomarkers and therapeutic targets, to improve current strategies for cancer diagnosis and treatment.

Original languageEnglish
Pages (from-to)96-106
Number of pages11
JournalSeminars in Cancer Biology
Volume35
DOIs
Publication statusPublished - Dec 1 2015

Keywords

  • Breast cancer
  • Cancer associated fibroblasts (CAF)
  • Gene expression
  • Inter-disease
  • Lung cancer
  • Prostate cancer

ASJC Scopus subject areas

  • Cancer Research

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