Complexity: Is it the real language of prostate cancer?

Fabio Grizzi, Gianluigi Taverna, Pier Carlo Muzzio, Pierpaolo Graziotti

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Despite years of intensive investigation into prostate cancer, it remains a major causeof death in men worldwide. Prostate cancer emerges from multiple alterations that inducechanges in expression patterns of genes and proteins that function in networks controllingcritical cellular events. Here, we briefly summarize several prognostic factors that havebeen proposed since serum prostate-specific antigen measurement was introduced over20 years ago for predicting the outcome of patients with prostate cancer. We hypothesizeprostate cancer as a complex dynamical disease using the basic principles of non-linearsystems and chaos theory. Irrespective of whether it is confirmed, our hypothesis mayhelp to clarify old concepts, categorize actual knowledge, and suggest alternativeapproaches to discovering additional markers with potential clinical value.

Original languageEnglish
Title of host publicationHypotheses in Clinical Medicine
PublisherNova Science Publishers, Inc.
Pages155-166
Number of pages12
ISBN (Print)9781622572762
Publication statusPublished - 2013

Fingerprint

Prostatic Neoplasms
Language
Nonlinear Dynamics
Prostate-Specific Antigen
Serum
Neoplasms
Proteins

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Grizzi, F., Taverna, G., Muzzio, P. C., & Graziotti, P. (2013). Complexity: Is it the real language of prostate cancer? In Hypotheses in Clinical Medicine (pp. 155-166). Nova Science Publishers, Inc..

Complexity : Is it the real language of prostate cancer? / Grizzi, Fabio; Taverna, Gianluigi; Muzzio, Pier Carlo; Graziotti, Pierpaolo.

Hypotheses in Clinical Medicine. Nova Science Publishers, Inc., 2013. p. 155-166.

Research output: Chapter in Book/Report/Conference proceedingChapter

Grizzi, F, Taverna, G, Muzzio, PC & Graziotti, P 2013, Complexity: Is it the real language of prostate cancer? in Hypotheses in Clinical Medicine. Nova Science Publishers, Inc., pp. 155-166.
Grizzi F, Taverna G, Muzzio PC, Graziotti P. Complexity: Is it the real language of prostate cancer? In Hypotheses in Clinical Medicine. Nova Science Publishers, Inc. 2013. p. 155-166
Grizzi, Fabio ; Taverna, Gianluigi ; Muzzio, Pier Carlo ; Graziotti, Pierpaolo. / Complexity : Is it the real language of prostate cancer?. Hypotheses in Clinical Medicine. Nova Science Publishers, Inc., 2013. pp. 155-166
@inbook{21e2b9f544de40c7b685068422a62b1a,
title = "Complexity: Is it the real language of prostate cancer?",
abstract = "Despite years of intensive investigation into prostate cancer, it remains a major causeof death in men worldwide. Prostate cancer emerges from multiple alterations that inducechanges in expression patterns of genes and proteins that function in networks controllingcritical cellular events. Here, we briefly summarize several prognostic factors that havebeen proposed since serum prostate-specific antigen measurement was introduced over20 years ago for predicting the outcome of patients with prostate cancer. We hypothesizeprostate cancer as a complex dynamical disease using the basic principles of non-linearsystems and chaos theory. Irrespective of whether it is confirmed, our hypothesis mayhelp to clarify old concepts, categorize actual knowledge, and suggest alternativeapproaches to discovering additional markers with potential clinical value.",
author = "Fabio Grizzi and Gianluigi Taverna and Muzzio, {Pier Carlo} and Pierpaolo Graziotti",
year = "2013",
language = "English",
isbn = "9781622572762",
pages = "155--166",
booktitle = "Hypotheses in Clinical Medicine",
publisher = "Nova Science Publishers, Inc.",

}

TY - CHAP

T1 - Complexity

T2 - Is it the real language of prostate cancer?

AU - Grizzi, Fabio

AU - Taverna, Gianluigi

AU - Muzzio, Pier Carlo

AU - Graziotti, Pierpaolo

PY - 2013

Y1 - 2013

N2 - Despite years of intensive investigation into prostate cancer, it remains a major causeof death in men worldwide. Prostate cancer emerges from multiple alterations that inducechanges in expression patterns of genes and proteins that function in networks controllingcritical cellular events. Here, we briefly summarize several prognostic factors that havebeen proposed since serum prostate-specific antigen measurement was introduced over20 years ago for predicting the outcome of patients with prostate cancer. We hypothesizeprostate cancer as a complex dynamical disease using the basic principles of non-linearsystems and chaos theory. Irrespective of whether it is confirmed, our hypothesis mayhelp to clarify old concepts, categorize actual knowledge, and suggest alternativeapproaches to discovering additional markers with potential clinical value.

AB - Despite years of intensive investigation into prostate cancer, it remains a major causeof death in men worldwide. Prostate cancer emerges from multiple alterations that inducechanges in expression patterns of genes and proteins that function in networks controllingcritical cellular events. Here, we briefly summarize several prognostic factors that havebeen proposed since serum prostate-specific antigen measurement was introduced over20 years ago for predicting the outcome of patients with prostate cancer. We hypothesizeprostate cancer as a complex dynamical disease using the basic principles of non-linearsystems and chaos theory. Irrespective of whether it is confirmed, our hypothesis mayhelp to clarify old concepts, categorize actual knowledge, and suggest alternativeapproaches to discovering additional markers with potential clinical value.

UR - http://www.scopus.com/inward/record.url?scp=84895363871&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84895363871&partnerID=8YFLogxK

M3 - Chapter

AN - SCOPUS:84895363871

SN - 9781622572762

SP - 155

EP - 166

BT - Hypotheses in Clinical Medicine

PB - Nova Science Publishers, Inc.

ER -