Complexity: Is it the real language of prostate cancer?

Fabio Grizzi, Gianluigi Taverna, Pier Carlo Muzzio, Pierpaolo Graziotti

Research output: Chapter in Book/Report/Conference proceedingChapter


Despite years of intensive investigation into prostate cancer, it remains a major causeof death in men worldwide. Prostate cancer emerges from multiple alterations that inducechanges in expression patterns of genes and proteins that function in networks controllingcritical cellular events. Here, we briefly summarize several prognostic factors that havebeen proposed since serum prostate-specific antigen measurement was introduced over20 years ago for predicting the outcome of patients with prostate cancer. We hypothesizeprostate cancer as a complex dynamical disease using the basic principles of non-linearsystems and chaos theory. Irrespective of whether it is confirmed, our hypothesis mayhelp to clarify old concepts, categorize actual knowledge, and suggest alternativeapproaches to discovering additional markers with potential clinical value.

Original languageEnglish
Title of host publicationHypotheses in Clinical Medicine
PublisherNova Science Publishers, Inc.
Number of pages12
ISBN (Print)9781622572762
Publication statusPublished - 2013

ASJC Scopus subject areas

  • Medicine(all)


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