Despite years of intensive investigation into prostate cancer, it remains a major causeof death in men worldwide. Prostate cancer emerges from multiple alterations that inducechanges in expression patterns of genes and proteins that function in networks controllingcritical cellular events. Here, we briefly summarize several prognostic factors that havebeen proposed since serum prostate-specific antigen measurement was introduced over20 years ago for predicting the outcome of patients with prostate cancer. We hypothesizeprostate cancer as a complex dynamical disease using the basic principles of non-linearsystems and chaos theory. Irrespective of whether it is confirmed, our hypothesis mayhelp to clarify old concepts, categorize actual knowledge, and suggest alternativeapproaches to discovering additional markers with potential clinical value.
|Title of host publication||Hypotheses in Clinical Medicine|
|Publisher||Nova Science Publishers, Inc.|
|Number of pages||12|
|Publication status||Published - 2013|
ASJC Scopus subject areas