Abstract
Despite years of intensive investigation into prostate cancer, it remains a major causeof death in men worldwide. Prostate cancer emerges from multiple alterations that inducechanges in expression patterns of genes and proteins that function in networks controllingcritical cellular events. Here, we briefly summarize several prognostic factors that havebeen proposed since serum prostate-specific antigen measurement was introduced over20 years ago for predicting the outcome of patients with prostate cancer. We hypothesizeprostate cancer as a complex dynamical disease using the basic principles of non-linearsystems and chaos theory. Irrespective of whether it is confirmed, our hypothesis mayhelp to clarify old concepts, categorize actual knowledge, and suggest alternativeapproaches to discovering additional markers with potential clinical value.
| Original language | English |
|---|---|
| Title of host publication | Hypotheses in Clinical Medicine |
| Publisher | Nova Science Publishers, Inc. |
| Pages | 155-166 |
| Number of pages | 12 |
| ISBN (Print) | 9781622572762 |
| Publication status | Published - 2013 |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Complexity : Is it the real language of prostate cancer? / Grizzi, Fabio; Taverna, Gianluigi; Muzzio, Pier Carlo; Graziotti, Pierpaolo.
Hypotheses in Clinical Medicine. Nova Science Publishers, Inc., 2013. p. 155-166.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Complexity
T2 - Is it the real language of prostate cancer?
AU - Grizzi, Fabio
AU - Taverna, Gianluigi
AU - Muzzio, Pier Carlo
AU - Graziotti, Pierpaolo
PY - 2013
Y1 - 2013
N2 - Despite years of intensive investigation into prostate cancer, it remains a major causeof death in men worldwide. Prostate cancer emerges from multiple alterations that inducechanges in expression patterns of genes and proteins that function in networks controllingcritical cellular events. Here, we briefly summarize several prognostic factors that havebeen proposed since serum prostate-specific antigen measurement was introduced over20 years ago for predicting the outcome of patients with prostate cancer. We hypothesizeprostate cancer as a complex dynamical disease using the basic principles of non-linearsystems and chaos theory. Irrespective of whether it is confirmed, our hypothesis mayhelp to clarify old concepts, categorize actual knowledge, and suggest alternativeapproaches to discovering additional markers with potential clinical value.
AB - Despite years of intensive investigation into prostate cancer, it remains a major causeof death in men worldwide. Prostate cancer emerges from multiple alterations that inducechanges in expression patterns of genes and proteins that function in networks controllingcritical cellular events. Here, we briefly summarize several prognostic factors that havebeen proposed since serum prostate-specific antigen measurement was introduced over20 years ago for predicting the outcome of patients with prostate cancer. We hypothesizeprostate cancer as a complex dynamical disease using the basic principles of non-linearsystems and chaos theory. Irrespective of whether it is confirmed, our hypothesis mayhelp to clarify old concepts, categorize actual knowledge, and suggest alternativeapproaches to discovering additional markers with potential clinical value.
UR - http://www.scopus.com/inward/record.url?scp=84895363871&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84895363871&partnerID=8YFLogxK
M3 - Chapter
AN - SCOPUS:84895363871
SN - 9781622572762
SP - 155
EP - 166
BT - Hypotheses in Clinical Medicine
PB - Nova Science Publishers, Inc.
ER -