Abstract
Background: Percutaneous endoscopic gastrostomy (PEG) is the most common endoscopic procedure used to provide nutritional support. Aim: To prospectively evaluate the mortality and complication incidences after PEG insertion or replacement. Methods: All patients who underwent PEG insertion or replacement were included. Details on patient characteristics, ongoing therapies, comorbidities, and indication for PEG placement/replacement were collected, along with informed consent form signatures. Early and late (30-day) complications and mortality were assessed. Results: 950 patients (47.1% male) were enrolled in 25 centers in Lombardy, a region of Northern Italy. Patient mean age was 73 years. 69.5% of patients had ASA status 3 or 4. First PEG placement was performed in 594 patients. Complication and mortality incidences were 4.8% and 5.2%, respectively. The most frequent complication was infection (50%), followed by bleeding (32.1%), tube dislodgment (14.3%), and buried bumper syndrome (3.6%). At multivariable analysis, age (OR 1.08 per 1-year increase, 95% CI, 1.0–1.16, p = 0.010) and BMI (OR 0.86 per 1-point increase, 95% CI, 0.77−0.96, p = 0.014) were factors associated with mortality. PEG replacement was carried out in 356 patients. Thirty-day mortality was 1.8%, while complications occurred in 1.7% of patients. Conclusions: Our data confirm that PEG placement is a safe procedure. Mortality was not related to the procedure itself, confirming that careful patient selection is warranted.
| Original language | English |
|---|---|
| Journal | Digestive and Liver Disease |
| DOIs | |
| Publication status | Published - Jan 1 2019 |
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Keywords
- Complications
- Mortality
- PEG
- Risk factors
- Short-term outcome
ASJC Scopus subject areas
- Hepatology
- Gastroenterology
Cite this
Complications and early mortality in percutaneous endoscopic gastrostomy placement in lombardy : A multicenter prospective cohort study. / Anderloni, Andrea; Di Leo, Milena; Barzaghi, Franco; Semeraro, Rossella; Meucci, Gianmichele; Marino, Roberta; Amato, Loretta; Frigerio, Mauro; Saladino, Valeria; Toldi, Anna; Manfredi, Guido; Redaelli, Alessandro; Feliziani, Marcella; De Roberto, Giuseppe; Boni, Francesca; Scacchi, Gianlorenzo; Mosca, Davide; Devani, Massimo; Arena, Monica; Massidda, Marco; Zanoni, Paolo; Ciscato, Camilla; Casini, Valentina; Beretta, Paolo; Forti, Edoardo; Salerno, Raffaele; Caramia, Vitantonio; Bianchetti, Mario; Tomba, Carolina; Evangelista, Andrea; Repici, Alessandro; Soncini, Marco; Maconi, Giovanni; Manes, Gianpiero; Gullotta, Renzo.
In: Digestive and Liver Disease, 01.01.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Complications and early mortality in percutaneous endoscopic gastrostomy placement in lombardy
T2 - A multicenter prospective cohort study
AU - Anderloni, Andrea
AU - Di Leo, Milena
AU - Barzaghi, Franco
AU - Semeraro, Rossella
AU - Meucci, Gianmichele
AU - Marino, Roberta
AU - Amato, Loretta
AU - Frigerio, Mauro
AU - Saladino, Valeria
AU - Toldi, Anna
AU - Manfredi, Guido
AU - Redaelli, Alessandro
AU - Feliziani, Marcella
AU - De Roberto, Giuseppe
AU - Boni, Francesca
AU - Scacchi, Gianlorenzo
AU - Mosca, Davide
AU - Devani, Massimo
AU - Arena, Monica
AU - Massidda, Marco
AU - Zanoni, Paolo
AU - Ciscato, Camilla
AU - Casini, Valentina
AU - Beretta, Paolo
AU - Forti, Edoardo
AU - Salerno, Raffaele
AU - Caramia, Vitantonio
AU - Bianchetti, Mario
AU - Tomba, Carolina
AU - Evangelista, Andrea
AU - Repici, Alessandro
AU - Soncini, Marco
AU - Maconi, Giovanni
AU - Manes, Gianpiero
AU - Gullotta, Renzo
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Background: Percutaneous endoscopic gastrostomy (PEG) is the most common endoscopic procedure used to provide nutritional support. Aim: To prospectively evaluate the mortality and complication incidences after PEG insertion or replacement. Methods: All patients who underwent PEG insertion or replacement were included. Details on patient characteristics, ongoing therapies, comorbidities, and indication for PEG placement/replacement were collected, along with informed consent form signatures. Early and late (30-day) complications and mortality were assessed. Results: 950 patients (47.1% male) were enrolled in 25 centers in Lombardy, a region of Northern Italy. Patient mean age was 73 years. 69.5% of patients had ASA status 3 or 4. First PEG placement was performed in 594 patients. Complication and mortality incidences were 4.8% and 5.2%, respectively. The most frequent complication was infection (50%), followed by bleeding (32.1%), tube dislodgment (14.3%), and buried bumper syndrome (3.6%). At multivariable analysis, age (OR 1.08 per 1-year increase, 95% CI, 1.0–1.16, p = 0.010) and BMI (OR 0.86 per 1-point increase, 95% CI, 0.77−0.96, p = 0.014) were factors associated with mortality. PEG replacement was carried out in 356 patients. Thirty-day mortality was 1.8%, while complications occurred in 1.7% of patients. Conclusions: Our data confirm that PEG placement is a safe procedure. Mortality was not related to the procedure itself, confirming that careful patient selection is warranted.
AB - Background: Percutaneous endoscopic gastrostomy (PEG) is the most common endoscopic procedure used to provide nutritional support. Aim: To prospectively evaluate the mortality and complication incidences after PEG insertion or replacement. Methods: All patients who underwent PEG insertion or replacement were included. Details on patient characteristics, ongoing therapies, comorbidities, and indication for PEG placement/replacement were collected, along with informed consent form signatures. Early and late (30-day) complications and mortality were assessed. Results: 950 patients (47.1% male) were enrolled in 25 centers in Lombardy, a region of Northern Italy. Patient mean age was 73 years. 69.5% of patients had ASA status 3 or 4. First PEG placement was performed in 594 patients. Complication and mortality incidences were 4.8% and 5.2%, respectively. The most frequent complication was infection (50%), followed by bleeding (32.1%), tube dislodgment (14.3%), and buried bumper syndrome (3.6%). At multivariable analysis, age (OR 1.08 per 1-year increase, 95% CI, 1.0–1.16, p = 0.010) and BMI (OR 0.86 per 1-point increase, 95% CI, 0.77−0.96, p = 0.014) were factors associated with mortality. PEG replacement was carried out in 356 patients. Thirty-day mortality was 1.8%, while complications occurred in 1.7% of patients. Conclusions: Our data confirm that PEG placement is a safe procedure. Mortality was not related to the procedure itself, confirming that careful patient selection is warranted.
KW - Complications
KW - Mortality
KW - PEG
KW - Risk factors
KW - Short-term outcome
UR - http://www.scopus.com/inward/record.url?scp=85064393915&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85064393915&partnerID=8YFLogxK
U2 - 10.1016/j.dld.2019.03.024
DO - 10.1016/j.dld.2019.03.024
M3 - Article
AN - SCOPUS:85064393915
JO - Digestive and Liver Disease
JF - Digestive and Liver Disease
SN - 1590-8658
ER -