Complications and early mortality in percutaneous endoscopic gastrostomy placement in lombardy: A multicenter prospective cohort study

Andrea Anderloni, Milena Di Leo, Franco Barzaghi, Rossella Semeraro, Gianmichele Meucci, Roberta Marino, Loretta Amato, Mauro Frigerio, Valeria Saladino, Anna Toldi, Guido Manfredi, Alessandro Redaelli, Marcella Feliziani, Giuseppe De Roberto, Francesca Boni, Gianlorenzo Scacchi, Davide Mosca, Massimo Devani, Monica Arena, Marco MassiddaPaolo Zanoni, Camilla Ciscato, Valentina Casini, Paolo Beretta, Edoardo Forti, Raffaele Salerno, Vitantonio Caramia, Mario Bianchetti, Carolina Tomba, Andrea Evangelista, Alessandro Repici, Marco Soncini, Giovanni Maconi, Gianpiero Manes, Renzo Gullotta

Research output: Contribution to journalArticlepeer-review


BACKGROUND: Percutaneous endoscopic gastrostomy (PEG) is the most common endoscopic procedure used to provide nutritional support.

AIM: To prospectively evaluate the mortality and complication incidences after PEG insertion or replacement.

METHODS: All patients who underwent PEG insertion or replacement were included. Details on patient characteristics, ongoing therapies, comorbidities, and indication for PEG placement/replacement were collected, along with informed consent form signatures. Early and late (30-day) complications and mortality were assessed.

RESULTS: 950 patients (47.1% male) were enrolled in 25 centers in Lombardy, a region of Northern Italy. Patient mean age was 73 years. 69.5% of patients had ASA status 3 or 4. First PEG placement was performed in 594 patients. Complication and mortality incidences were 4.8% and 5.2%, respectively. The most frequent complication was infection (50%), followed by bleeding (32.1%), tube dislodgment (14.3%), and buried bumper syndrome (3.6%). At multivariable analysis, age (OR 1.08 per 1-year increase, 95% CI, 1.0-1.16, p = 0.010) and BMI (OR 0.86 per 1-point increase, 95% CI, 0.77-0.96, p = 0.014) were factors associated with mortality. PEG replacement was carried out in 356 patients. Thirty-day mortality was 1.8%, while complications occurred in 1.7% of patients.

CONCLUSIONS: Our data confirm that PEG placement is a safe procedure. Mortality was not related to the procedure itself, confirming that careful patient selection is warranted.

Original languageEnglish
Pages (from-to)1380-1387
Number of pages8
JournalDig. Liver Dis.
Issue number10
Publication statusPublished - Oct 2019


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