TY - JOUR
T1 - Complications and risk factors for severe outcome in children with measles
AU - Group, SITIP Measles Study
AU - Lo Vecchio, Andrea
AU - Krzysztofiak, Andrzej
AU - Montagnani, Carlotta
AU - Valentini, Piero
AU - Rossi, Nadia
AU - Garazzino, Silvia
AU - Raffaldi, Irene
AU - Di Gangi, Maria
AU - Esposito, Susanna
AU - Vecchi, Barbara
AU - Melzi, Maria Luisa
AU - Lanari, Marcello
AU - Zavarise, Giorgio
AU - Bosis, Samantha
AU - Valenzise, Mariella
AU - Cazzato, Salvatore
AU - Sacco, Michele
AU - Govoni, Maria Rita
AU - Mozzo, Elena
AU - Cambriglia, Maria Donata
AU - Bruzzese, Eugenia
AU - Di Camillo, Chiara
AU - Pata, Davide
AU - Graziosi, Alessandro
AU - Sala, Debora
AU - Magurano, Fabio
AU - Villani, Alberto
AU - Guarino, Alfredo
AU - Galli, Luisa
N1 - © Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.
PY - 2019/1/12
Y1 - 2019/1/12
N2 - OBJECTIVE AND DESIGN: Risk factors for severe measles are poorly investigated in high-income countries. The Italian Society for Paediatric Infectious Diseases conducted a retrospective study in children hospitalised for measles from January 2016 to August 2017 to investigate the risk factors for severe outcome defined by the presence of long-lasting sequelae, need of intensive care or death.RESULTS: Nineteen hospitals enrolled 249 children (median age 14.5 months): 207 (83%) children developed a complication and 3 (1%) died. Neutropaenia was more commonly reported in children with B3-genotype compared with other genotypes (29.5% vs 7.7%, p=0.01). Pancreatitis (adjusted OR [aOR] 9.19, p=0.01) and encephalitis (aOR 7.02, p=0.04) were related to severe outcome in multivariable analysis, as well as C reactive protein (CRP) (aOR 1.1, p=0.028), the increase of which predicted severe outcome (area under the receiver operating characteristic curve 0.67, 95%\ CI 0.52 to 0.82). CRP values >2\ mg/dL were related to higher risk of complications (OR 2.0, 95%\ CI 1.15 to 3.7, p=0.01) or severe outcome (OR 4.13, 95%\ CI 1.43 to 11.8, p
AB - OBJECTIVE AND DESIGN: Risk factors for severe measles are poorly investigated in high-income countries. The Italian Society for Paediatric Infectious Diseases conducted a retrospective study in children hospitalised for measles from January 2016 to August 2017 to investigate the risk factors for severe outcome defined by the presence of long-lasting sequelae, need of intensive care or death.RESULTS: Nineteen hospitals enrolled 249 children (median age 14.5 months): 207 (83%) children developed a complication and 3 (1%) died. Neutropaenia was more commonly reported in children with B3-genotype compared with other genotypes (29.5% vs 7.7%, p=0.01). Pancreatitis (adjusted OR [aOR] 9.19, p=0.01) and encephalitis (aOR 7.02, p=0.04) were related to severe outcome in multivariable analysis, as well as C reactive protein (CRP) (aOR 1.1, p=0.028), the increase of which predicted severe outcome (area under the receiver operating characteristic curve 0.67, 95%\ CI 0.52 to 0.82). CRP values >2\ mg/dL were related to higher risk of complications (OR 2.0, 95%\ CI 1.15 to 3.7, p=0.01) or severe outcome (OR 4.13, 95%\ CI 1.43 to 11.8, p
U2 - 10.1136/archdischild-2018-315290
DO - 10.1136/archdischild-2018-315290
M3 - Article
JO - Archives of Disease in Childhood
JF - Archives of Disease in Childhood
SN - 0003-9888
ER -