Complications and risk factors for severe outcome in children with measles

SITIP Measles Study Group, Andrea Lo Vecchio, Andrzej Krzysztofiak, Carlotta Montagnani, Piero Valentini, Nadia Rossi, Silvia Garazzino, Irene Raffaldi, Maria Di Gangi, Susanna Esposito, Barbara Vecchi, Maria Luisa Melzi, Marcello Lanari, Giorgio Zavarise, Samantha Bosis, Mariella Valenzise, Salvatore Cazzato, Michele Sacco, Maria Rita Govoni, Elena MozzoMaria Donata Cambriglia, Eugenia Bruzzese, Chiara Di Camillo, Davide Pata, Alessandro Graziosi, Debora Sala, Fabio Magurano, Alberto Villani, Alfredo Guarino, Luisa Galli

Research output: Contribution to journalArticle

Abstract

OBJECTIVE AND DESIGN: Risk factors for severe measles are poorly investigated in high-income countries. The Italian Society for Paediatric Infectious Diseases conducted a retrospective study in children hospitalised for measles from January 2016 to August 2017 to investigate the risk factors for severe outcome defined by the presence of long-lasting sequelae, need of intensive care or death.RESULTS: Nineteen hospitals enrolled 249 children (median age 14.5 months): 207 (83%) children developed a complication and 3 (1%) died. Neutropaenia was more commonly reported in children with B3-genotype compared with other genotypes (29.5% vs 7.7%, p=0.01). Pancreatitis (adjusted OR [aOR] 9.19, p=0.01) and encephalitis (aOR 7.02, p=0.04) were related to severe outcome in multivariable analysis, as well as C reactive protein (CRP) (aOR 1.1, p=0.028), the increase of which predicted severe outcome (area under the receiver operating characteristic curve 0.67, 95%\ CI 0.52 to 0.82). CRP values >2\ mg/dL were related to higher risk of complications (OR 2.0, 95%\ CI 1.15 to 3.7, p=0.01) or severe outcome (OR 4.13, 95%\ CI 1.43 to 11.8, p
Original languageEnglish
JournalArchives of Disease in Childhood
DOIs
Publication statusPublished - Jan 12 2019

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Measles
C-Reactive Protein
Genotype
Hospitalized Child
Encephalitis
Critical Care
ROC Curve
Pancreatitis
Communicable Diseases
Retrospective Studies
Pediatrics

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Complications and risk factors for severe outcome in children with measles. / Group, SITIP Measles Study; Lo Vecchio, Andrea; Krzysztofiak, Andrzej; Montagnani, Carlotta; Valentini, Piero; Rossi, Nadia; Garazzino, Silvia; Raffaldi, Irene; Di Gangi, Maria; Esposito, Susanna; Vecchi, Barbara; Melzi, Maria Luisa; Lanari, Marcello; Zavarise, Giorgio; Bosis, Samantha; Valenzise, Mariella; Cazzato, Salvatore; Sacco, Michele; Govoni, Maria Rita; Mozzo, Elena; Cambriglia, Maria Donata; Bruzzese, Eugenia; Di Camillo, Chiara; Pata, Davide; Graziosi, Alessandro; Sala, Debora; Magurano, Fabio; Villani, Alberto; Guarino, Alfredo; Galli, Luisa.

In: Archives of Disease in Childhood, 12.01.2019.

Research output: Contribution to journalArticle

Group, SITIPMS, Lo Vecchio, A, Krzysztofiak, A, Montagnani, C, Valentini, P, Rossi, N, Garazzino, S, Raffaldi, I, Di Gangi, M, Esposito, S, Vecchi, B, Melzi, ML, Lanari, M, Zavarise, G, Bosis, S, Valenzise, M, Cazzato, S, Sacco, M, Govoni, MR, Mozzo, E, Cambriglia, MD, Bruzzese, E, Di Camillo, C, Pata, D, Graziosi, A, Sala, D, Magurano, F, Villani, A, Guarino, A & Galli, L 2019, 'Complications and risk factors for severe outcome in children with measles', Archives of Disease in Childhood. https://doi.org/10.1136/archdischild-2018-315290
Group, SITIP Measles Study ; Lo Vecchio, Andrea ; Krzysztofiak, Andrzej ; Montagnani, Carlotta ; Valentini, Piero ; Rossi, Nadia ; Garazzino, Silvia ; Raffaldi, Irene ; Di Gangi, Maria ; Esposito, Susanna ; Vecchi, Barbara ; Melzi, Maria Luisa ; Lanari, Marcello ; Zavarise, Giorgio ; Bosis, Samantha ; Valenzise, Mariella ; Cazzato, Salvatore ; Sacco, Michele ; Govoni, Maria Rita ; Mozzo, Elena ; Cambriglia, Maria Donata ; Bruzzese, Eugenia ; Di Camillo, Chiara ; Pata, Davide ; Graziosi, Alessandro ; Sala, Debora ; Magurano, Fabio ; Villani, Alberto ; Guarino, Alfredo ; Galli, Luisa. / Complications and risk factors for severe outcome in children with measles. In: Archives of Disease in Childhood. 2019.
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title = "Complications and risk factors for severe outcome in children with measles",
abstract = "OBJECTIVE AND DESIGN: Risk factors for severe measles are poorly investigated in high-income countries. The Italian Society for Paediatric Infectious Diseases conducted a retrospective study in children hospitalised for measles from January 2016 to August 2017 to investigate the risk factors for severe outcome defined by the presence of long-lasting sequelae, need of intensive care or death.RESULTS: Nineteen hospitals enrolled 249 children (median age 14.5 months): 207 (83{\%}) children developed a complication and 3 (1{\%}) died. Neutropaenia was more commonly reported in children with B3-genotype compared with other genotypes (29.5{\%} vs 7.7{\%}, p=0.01). Pancreatitis (adjusted OR [aOR] 9.19, p=0.01) and encephalitis (aOR 7.02, p=0.04) were related to severe outcome in multivariable analysis, as well as C reactive protein (CRP) (aOR 1.1, p=0.028), the increase of which predicted severe outcome (area under the receiver operating characteristic curve 0.67, 95{\%}\ CI 0.52 to 0.82). CRP values >2\ mg/dL were related to higher risk of complications (OR 2.0, 95{\%}\ CI 1.15 to 3.7, p=0.01) or severe outcome (OR 4.13, 95{\%}\ CI 1.43 to 11.8, p",
author = "Group, {SITIP Measles Study} and {Lo Vecchio}, Andrea and Andrzej Krzysztofiak and Carlotta Montagnani and Piero Valentini and Nadia Rossi and Silvia Garazzino and Irene Raffaldi and {Di Gangi}, Maria and Susanna Esposito and Barbara Vecchi and Melzi, {Maria Luisa} and Marcello Lanari and Giorgio Zavarise and Samantha Bosis and Mariella Valenzise and Salvatore Cazzato and Michele Sacco and Govoni, {Maria Rita} and Elena Mozzo and Cambriglia, {Maria Donata} and Eugenia Bruzzese and {Di Camillo}, Chiara and Davide Pata and Alessandro Graziosi and Debora Sala and Fabio Magurano and Alberto Villani and Alfredo Guarino and Luisa Galli",
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TY - JOUR

T1 - Complications and risk factors for severe outcome in children with measles

AU - Group, SITIP Measles Study

AU - Lo Vecchio, Andrea

AU - Krzysztofiak, Andrzej

AU - Montagnani, Carlotta

AU - Valentini, Piero

AU - Rossi, Nadia

AU - Garazzino, Silvia

AU - Raffaldi, Irene

AU - Di Gangi, Maria

AU - Esposito, Susanna

AU - Vecchi, Barbara

AU - Melzi, Maria Luisa

AU - Lanari, Marcello

AU - Zavarise, Giorgio

AU - Bosis, Samantha

AU - Valenzise, Mariella

AU - Cazzato, Salvatore

AU - Sacco, Michele

AU - Govoni, Maria Rita

AU - Mozzo, Elena

AU - Cambriglia, Maria Donata

AU - Bruzzese, Eugenia

AU - Di Camillo, Chiara

AU - Pata, Davide

AU - Graziosi, Alessandro

AU - Sala, Debora

AU - Magurano, Fabio

AU - Villani, Alberto

AU - Guarino, Alfredo

AU - Galli, Luisa

N1 - © Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.

PY - 2019/1/12

Y1 - 2019/1/12

N2 - OBJECTIVE AND DESIGN: Risk factors for severe measles are poorly investigated in high-income countries. The Italian Society for Paediatric Infectious Diseases conducted a retrospective study in children hospitalised for measles from January 2016 to August 2017 to investigate the risk factors for severe outcome defined by the presence of long-lasting sequelae, need of intensive care or death.RESULTS: Nineteen hospitals enrolled 249 children (median age 14.5 months): 207 (83%) children developed a complication and 3 (1%) died. Neutropaenia was more commonly reported in children with B3-genotype compared with other genotypes (29.5% vs 7.7%, p=0.01). Pancreatitis (adjusted OR [aOR] 9.19, p=0.01) and encephalitis (aOR 7.02, p=0.04) were related to severe outcome in multivariable analysis, as well as C reactive protein (CRP) (aOR 1.1, p=0.028), the increase of which predicted severe outcome (area under the receiver operating characteristic curve 0.67, 95%\ CI 0.52 to 0.82). CRP values >2\ mg/dL were related to higher risk of complications (OR 2.0, 95%\ CI 1.15 to 3.7, p=0.01) or severe outcome (OR 4.13, 95%\ CI 1.43 to 11.8, p

AB - OBJECTIVE AND DESIGN: Risk factors for severe measles are poorly investigated in high-income countries. The Italian Society for Paediatric Infectious Diseases conducted a retrospective study in children hospitalised for measles from January 2016 to August 2017 to investigate the risk factors for severe outcome defined by the presence of long-lasting sequelae, need of intensive care or death.RESULTS: Nineteen hospitals enrolled 249 children (median age 14.5 months): 207 (83%) children developed a complication and 3 (1%) died. Neutropaenia was more commonly reported in children with B3-genotype compared with other genotypes (29.5% vs 7.7%, p=0.01). Pancreatitis (adjusted OR [aOR] 9.19, p=0.01) and encephalitis (aOR 7.02, p=0.04) were related to severe outcome in multivariable analysis, as well as C reactive protein (CRP) (aOR 1.1, p=0.028), the increase of which predicted severe outcome (area under the receiver operating characteristic curve 0.67, 95%\ CI 0.52 to 0.82). CRP values >2\ mg/dL were related to higher risk of complications (OR 2.0, 95%\ CI 1.15 to 3.7, p=0.01) or severe outcome (OR 4.13, 95%\ CI 1.43 to 11.8, p

U2 - 10.1136/archdischild-2018-315290

DO - 10.1136/archdischild-2018-315290

M3 - Article

JO - Archives of Disease in Childhood

JF - Archives of Disease in Childhood

SN - 0003-9888

ER -