Complications, morbidity and mortality of nonalcoholic fatty liver disease: Metabolism: Clinical and Experimental

A. Mantovani, E. Scorletti, A. Mosca, A. Alisi, C.D. Byrne, G. Targher

Research output: Contribution to journalArticlepeer-review


Nonalcoholic fatty liver disease (NAFLD) is an increasingly recognized public health problem, affecting up to a quarter of the world's adult population. The burden of NAFLD is influenced by the epidemics of obesity and type 2 diabetes mellitus (T2DM) and the prevalence of these conditions is not expected to decrease in the forthcoming decades. Consequently, the burden of NAFLD-related liver complications (non-alcoholic steatohepatitis [NASH], cirrhosis and hepatocellular carcinoma) and the need for life-saving liver transplantation are also expected to increase further in the near future. A large body of clinical evidence indicates that NAFLD is associated not only with increased liver-related morbidity and mortality, but also with an increased risk of developing other important extra-hepatic diseases, such as cardiovascular disease (that is the predominant cause of death in patients with NAFLD), extra-hepatic cancers (mainly colorectal cancers), T2DM and chronic kidney disease. Thus, NAFLD creates a considerable health and economic burden worldwide and often results in poor quality of life. This narrative review provides an overview of the current literature on main complications, morbidity and mortality of this common and burdensome liver disease. © 2020 Elsevier Inc.
Original languageEnglish
JournalMetab. Clin. Exp.
Publication statusPublished - 2020


  • Complications
  • CVD
  • Epidemiology
  • Mortality
  • NASH
  • T2DM
  • all cause mortality
  • Article
  • cardiovascular risk
  • chronic kidney failure
  • complication
  • diabetes mellitus
  • disease burden
  • heart disease
  • human
  • liver cell carcinoma
  • liver cirrhosis
  • liver transplantation
  • malignant neoplasm
  • morbidity
  • mortality
  • nonalcoholic fatty liver
  • pathogenesis
  • priority journal
  • cardiovascular disease
  • liver
  • non insulin dependent diabetes mellitus
  • pathology
  • prevalence
  • procedures
  • Cardiovascular Diseases
  • Diabetes Mellitus, Type 2
  • Humans
  • Liver
  • Liver Transplantation
  • Morbidity
  • Non-alcoholic Fatty Liver Disease
  • Prevalence


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