Complications of central neck dissection in patients with papillary thyroid carcinoma: Results of a study on 1087 patients and review of the literature

Davide Giordano, Roberto Valcavi, Geoffrey B. Thompson, Corrado Pedroni, Luigi Renna, Paolo Gradoni, Verter Barbieri

Research output: Contribution to journalArticle

170 Citations (Scopus)

Abstract

Background: Prophylactic central neck dissection (CND) has been proposed in the treatment of patients affected by papillary thyroid carcinoma (PTC) with clinically negative neck lymph nodes. The procedure allows pathologic staging of lymph nodes of the central compartment and treatment of the micrometastases. Nevertheless, the morbidity that its routine use adds to the total thyroidectomy must be taken into account. The aim of this study was to characterize the morbidity that CND adds to the total thyroidectomy. Methods: This was a retrospective study of 1087 patients with PTC and clinically negative neck lymph nodes. Patients were divided into three study groups: Group A, total thyroidectomy; Group B, total thyroidectomy and ipsilateral CND; Group C, total thyroidectomy and bilateral CND. Primary endpoints of the study were evaluated by comparing the rates of transient and permanent recurrent laryngeal nerve (RLN) injury and hypoparathyroidism in the three study groups. Results: Analysis of data showed no significant differences in the rate of transient (Group A: 3.6%, Group B: 3.9%, and Group C: 5.5%; p=0.404) and permanent (Group A: 1%, Group B: 0.5%, and Group C: 2.3%; p=0.099) RLN injury between the three study groups. Both ipsilateral CND and bilateral CND were associated with a higher rate of transient hypoparathyroidism (Group: A 27.7%, Group B: 36.1%, and Group C: 51.9%; p=0.014; odds ratio [OR]: 1.477; 95% confidence interval [CI]: 1.091-2.001; p

Original languageEnglish
Pages (from-to)911-917
Number of pages7
JournalThyroid
Volume22
Issue number9
DOIs
Publication statusPublished - Sep 1 2012

Fingerprint

Neck Dissection
Thyroidectomy
Recurrent Laryngeal Nerve Injuries
Hypoparathyroidism
Lymph Nodes
Neck
Morbidity
Neoplasm Micrometastasis
Papillary Thyroid cancer
Retrospective Studies
Odds Ratio
Confidence Intervals
Therapeutics

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Complications of central neck dissection in patients with papillary thyroid carcinoma : Results of a study on 1087 patients and review of the literature. / Giordano, Davide; Valcavi, Roberto; Thompson, Geoffrey B.; Pedroni, Corrado; Renna, Luigi; Gradoni, Paolo; Barbieri, Verter.

In: Thyroid, Vol. 22, No. 9, 01.09.2012, p. 911-917.

Research output: Contribution to journalArticle

Giordano, Davide ; Valcavi, Roberto ; Thompson, Geoffrey B. ; Pedroni, Corrado ; Renna, Luigi ; Gradoni, Paolo ; Barbieri, Verter. / Complications of central neck dissection in patients with papillary thyroid carcinoma : Results of a study on 1087 patients and review of the literature. In: Thyroid. 2012 ; Vol. 22, No. 9. pp. 911-917.
@article{ef7d48eb231a413a8ff6dd3700950444,
title = "Complications of central neck dissection in patients with papillary thyroid carcinoma: Results of a study on 1087 patients and review of the literature",
abstract = "Background: Prophylactic central neck dissection (CND) has been proposed in the treatment of patients affected by papillary thyroid carcinoma (PTC) with clinically negative neck lymph nodes. The procedure allows pathologic staging of lymph nodes of the central compartment and treatment of the micrometastases. Nevertheless, the morbidity that its routine use adds to the total thyroidectomy must be taken into account. The aim of this study was to characterize the morbidity that CND adds to the total thyroidectomy. Methods: This was a retrospective study of 1087 patients with PTC and clinically negative neck lymph nodes. Patients were divided into three study groups: Group A, total thyroidectomy; Group B, total thyroidectomy and ipsilateral CND; Group C, total thyroidectomy and bilateral CND. Primary endpoints of the study were evaluated by comparing the rates of transient and permanent recurrent laryngeal nerve (RLN) injury and hypoparathyroidism in the three study groups. Results: Analysis of data showed no significant differences in the rate of transient (Group A: 3.6{\%}, Group B: 3.9{\%}, and Group C: 5.5{\%}; p=0.404) and permanent (Group A: 1{\%}, Group B: 0.5{\%}, and Group C: 2.3{\%}; p=0.099) RLN injury between the three study groups. Both ipsilateral CND and bilateral CND were associated with a higher rate of transient hypoparathyroidism (Group: A 27.7{\%}, Group B: 36.1{\%}, and Group C: 51.9{\%}; p=0.014; odds ratio [OR]: 1.477; 95{\%} confidence interval [CI]: 1.091-2.001; p",
author = "Davide Giordano and Roberto Valcavi and Thompson, {Geoffrey B.} and Corrado Pedroni and Luigi Renna and Paolo Gradoni and Verter Barbieri",
year = "2012",
month = "9",
day = "1",
doi = "10.1089/thy.2012.0011",
language = "English",
volume = "22",
pages = "911--917",
journal = "Thyroid",
issn = "1050-7256",
publisher = "Mary Ann Liebert Inc.",
number = "9",

}

TY - JOUR

T1 - Complications of central neck dissection in patients with papillary thyroid carcinoma

T2 - Results of a study on 1087 patients and review of the literature

AU - Giordano, Davide

AU - Valcavi, Roberto

AU - Thompson, Geoffrey B.

AU - Pedroni, Corrado

AU - Renna, Luigi

AU - Gradoni, Paolo

AU - Barbieri, Verter

PY - 2012/9/1

Y1 - 2012/9/1

N2 - Background: Prophylactic central neck dissection (CND) has been proposed in the treatment of patients affected by papillary thyroid carcinoma (PTC) with clinically negative neck lymph nodes. The procedure allows pathologic staging of lymph nodes of the central compartment and treatment of the micrometastases. Nevertheless, the morbidity that its routine use adds to the total thyroidectomy must be taken into account. The aim of this study was to characterize the morbidity that CND adds to the total thyroidectomy. Methods: This was a retrospective study of 1087 patients with PTC and clinically negative neck lymph nodes. Patients were divided into three study groups: Group A, total thyroidectomy; Group B, total thyroidectomy and ipsilateral CND; Group C, total thyroidectomy and bilateral CND. Primary endpoints of the study were evaluated by comparing the rates of transient and permanent recurrent laryngeal nerve (RLN) injury and hypoparathyroidism in the three study groups. Results: Analysis of data showed no significant differences in the rate of transient (Group A: 3.6%, Group B: 3.9%, and Group C: 5.5%; p=0.404) and permanent (Group A: 1%, Group B: 0.5%, and Group C: 2.3%; p=0.099) RLN injury between the three study groups. Both ipsilateral CND and bilateral CND were associated with a higher rate of transient hypoparathyroidism (Group: A 27.7%, Group B: 36.1%, and Group C: 51.9%; p=0.014; odds ratio [OR]: 1.477; 95% confidence interval [CI]: 1.091-2.001; p

AB - Background: Prophylactic central neck dissection (CND) has been proposed in the treatment of patients affected by papillary thyroid carcinoma (PTC) with clinically negative neck lymph nodes. The procedure allows pathologic staging of lymph nodes of the central compartment and treatment of the micrometastases. Nevertheless, the morbidity that its routine use adds to the total thyroidectomy must be taken into account. The aim of this study was to characterize the morbidity that CND adds to the total thyroidectomy. Methods: This was a retrospective study of 1087 patients with PTC and clinically negative neck lymph nodes. Patients were divided into three study groups: Group A, total thyroidectomy; Group B, total thyroidectomy and ipsilateral CND; Group C, total thyroidectomy and bilateral CND. Primary endpoints of the study were evaluated by comparing the rates of transient and permanent recurrent laryngeal nerve (RLN) injury and hypoparathyroidism in the three study groups. Results: Analysis of data showed no significant differences in the rate of transient (Group A: 3.6%, Group B: 3.9%, and Group C: 5.5%; p=0.404) and permanent (Group A: 1%, Group B: 0.5%, and Group C: 2.3%; p=0.099) RLN injury between the three study groups. Both ipsilateral CND and bilateral CND were associated with a higher rate of transient hypoparathyroidism (Group: A 27.7%, Group B: 36.1%, and Group C: 51.9%; p=0.014; odds ratio [OR]: 1.477; 95% confidence interval [CI]: 1.091-2.001; p

UR - http://www.scopus.com/inward/record.url?scp=84865605841&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84865605841&partnerID=8YFLogxK

U2 - 10.1089/thy.2012.0011

DO - 10.1089/thy.2012.0011

M3 - Article

C2 - 22827494

AN - SCOPUS:84865605841

VL - 22

SP - 911

EP - 917

JO - Thyroid

JF - Thyroid

SN - 1050-7256

IS - 9

ER -