Components of the CtBP1/BARS-dependent fission machinery

Carmen Valente, Alberto Luini, Daniela Corda

Research output: Contribution to journalArticlepeer-review


The brefeldin A ADP-ribosylated substrate, a member of the C-terminal-binding protein family that is referred to as CtBP1/BARS, is a dual-function protein that acts as a transcriptional co-repressor in the nucleus and as an inducer of membrane fission in the cytoplasm. In this review, we first discuss the mechanisms that enable CtBP1/BARS to shift between the nuclear transcriptional co-repressor and the cytosolic fission-inducing activities. Then, we focus on the role of CtBP1/BARS in membrane fission. CtBP1/BARS controls several fission events including macropinocytosis, fluid-phase endocytosis, COPI-coated vesicle formation, basolaterally directed post-Golgi carrier formation, and Golgi partitioning in mitosis. We report on recent advances in our understanding of the CtBP1/BARS membrane fission machineries that operate at the trans-side and at the cis-side of the Golgi complex. Specifically, we discuss how these machineries are assembled and regulated, and how they operate in the formation of the basolaterally directed post-Golgi carriers.

Original languageEnglish
Pages (from-to)407-421
Number of pages15
JournalHistochemistry and Cell Biology
Issue number4
Publication statusPublished - 2013


  • ADP ribosylation
  • CtBP1/BARS
  • Golgi checkpoint
  • Golgi complex
  • Membrane fission
  • Mitosis

ASJC Scopus subject areas

  • Cell Biology
  • Histology
  • Medical Laboratory Technology
  • Molecular Biology


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