Comportamento di alcune attivita' enzimatiche del siero di sangue nel diabete mellito, con particolare riferimento agli enzimi epatospecifici

The Authors have studied the glutamic-oxalacetic (GOT) and glutamic-pyruvic (GPT) transaminase activities, together with aldolase, sorbitol-dehydrogenase (SODH), glutamic-dehydrogenase (GLDH), isocitric-dehydrogenase (ICDH) and arginase activity of the serum in 138 diabetics. They observe that while the average values do not show any significant changes compared with the normal, marked increases are seen in some patient, with a different frequency for the various enzymes studied (2% for GOT, 3% for GPT, 13% for aldolase, 17% for SODH, 11% for GLDH, 9% for ICDH, and 2% for arginase). As the highest percentage of increases was observed in the case of enzymes of mainly hepatic localisation, and thus possessing remarkable hepatic specificity (SODH), the Authors admit that the serum enzymatic increases observed must be considered as indices of the existence of hepatic involvement.