TY - JOUR
T1 - Composite chronic lymphocytic leukemia/small lymphocytic lymphoma and follicular lymphoma are biclonal lymphomas
T2 - A report of two cases
AU - Boiocchi, Leonardo
AU - Witter, Rosanny Espinal
AU - He, Bing
AU - Subramaniyam, Shivakumar
AU - Mathew, Susan
AU - Nie, Kui
AU - Cerutti, Andrea
AU - Coleman, Morton
AU - Knowles, Daniel M.
AU - Orazi, Attilio
AU - Tam, Wayne
PY - 2012/4
Y1 - 2012/4
N2 - Composite lymphomas (CLs) consisting of 2 indolent B-cell lymphomas are rare. We present 2 CL cases composed of chronic lymphocytic leukemia (CLL) and follicular lymphoma (FL), each with unique clinicopathologic features. In the first case, the FL was negative for IGH-BCL2 and harbored a novel IGH-associated translocation; in the second case, the CL manifested in the skin. The individual components in both CLs were derived from different B-cell clones. This is the first complete characterization, including molecular analysis, of CLs composed of leukemic CLL and FL and the first report of a cutaneous CL derived from 2 low-grade B cell lymphomas. Our results provide additional supporting evidence that CLs of indolent B-cell lymphomas are biclonal and suggest that they are pathogenetically different from CLs composed of a low-grade B-cell lymphoma and an aggressive B-cell lymphoma or Hodgkin lymphoma, which are usually clonally related. Copyright
AB - Composite lymphomas (CLs) consisting of 2 indolent B-cell lymphomas are rare. We present 2 CL cases composed of chronic lymphocytic leukemia (CLL) and follicular lymphoma (FL), each with unique clinicopathologic features. In the first case, the FL was negative for IGH-BCL2 and harbored a novel IGH-associated translocation; in the second case, the CL manifested in the skin. The individual components in both CLs were derived from different B-cell clones. This is the first complete characterization, including molecular analysis, of CLs composed of leukemic CLL and FL and the first report of a cutaneous CL derived from 2 low-grade B cell lymphomas. Our results provide additional supporting evidence that CLs of indolent B-cell lymphomas are biclonal and suggest that they are pathogenetically different from CLs composed of a low-grade B-cell lymphoma and an aggressive B-cell lymphoma or Hodgkin lymphoma, which are usually clonally related. Copyright
KW - Chronic lymphocytic leukemia
KW - Clone
KW - Composite lymphoma
KW - Follicular lymphoma
KW - Laser microdissection
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U2 - 10.1309/AJCPHXO5UGW2OELA
DO - 10.1309/AJCPHXO5UGW2OELA
M3 - Article
C2 - 22431543
AN - SCOPUS:84860579187
VL - 137
SP - 647
EP - 659
JO - American Journal of Clinical Pathology
JF - American Journal of Clinical Pathology
SN - 0002-9173
IS - 4
ER -