Composite chronic lymphocytic leukemia/small lymphocytic lymphoma and follicular lymphoma are biclonal lymphomas: A report of two cases

Leonardo Boiocchi, Rosanny Espinal Witter, Bing He, Shivakumar Subramaniyam, Susan Mathew, Kui Nie, Andrea Cerutti, Morton Coleman, Daniel M. Knowles, Attilio Orazi, Wayne Tam

Research output: Contribution to journalArticle

Abstract

Composite lymphomas (CLs) consisting of 2 indolent B-cell lymphomas are rare. We present 2 CL cases composed of chronic lymphocytic leukemia (CLL) and follicular lymphoma (FL), each with unique clinicopathologic features. In the first case, the FL was negative for IGH-BCL2 and harbored a novel IGH-associated translocation; in the second case, the CL manifested in the skin. The individual components in both CLs were derived from different B-cell clones. This is the first complete characterization, including molecular analysis, of CLs composed of leukemic CLL and FL and the first report of a cutaneous CL derived from 2 low-grade B cell lymphomas. Our results provide additional supporting evidence that CLs of indolent B-cell lymphomas are biclonal and suggest that they are pathogenetically different from CLs composed of a low-grade B-cell lymphoma and an aggressive B-cell lymphoma or Hodgkin lymphoma, which are usually clonally related. Copyright

Original languageEnglish
Pages (from-to)647-659
Number of pages13
JournalAmerican Journal of Clinical Pathology
Volume137
Issue number4
DOIs
Publication statusPublished - Apr 2012

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Keywords

  • Chronic lymphocytic leukemia
  • Clone
  • Composite lymphoma
  • Follicular lymphoma
  • Laser microdissection

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Boiocchi, L., Witter, R. E., He, B., Subramaniyam, S., Mathew, S., Nie, K., Cerutti, A., Coleman, M., Knowles, D. M., Orazi, A., & Tam, W. (2012). Composite chronic lymphocytic leukemia/small lymphocytic lymphoma and follicular lymphoma are biclonal lymphomas: A report of two cases. American Journal of Clinical Pathology, 137(4), 647-659. https://doi.org/10.1309/AJCPHXO5UGW2OELA