Composite reconstruction in advanced cancer of the mouth floor: Autogenous frozen-thawed mandibular bone and free flaps

Research output: Contribution to journalArticle

Abstract

Mandibular symphyseal resection requires composite reconstructions, often with unsatisfactory morphofunctional results. Seven patients with advanced squamous cell carcinoma of the floor of the mouth underwent block resection with immediate reconstruction, using the removed mandible treated with liquid nitrogen and covered with a free forearm flap. In all cases, the resection was radical and no major postoperative complications occurred. Two patients died in 6 months for distant metastases and regional recurrence. In the other 5 patients, no local recurrence occurred at a mean follow-up of 52 months (36-70). Immediate cosmetic and functional results were good. Of the 5 patients, 4 had late complications requiring further surgery. This technique of bone reimplantation produces no donor site morbidity, perfect immediate morphological result, and is of low cost. The free forearm flap is effective in sealing the oral cavity, though further clinical and experimental studies are necessary to reduce late local complications.

Original languageEnglish
Pages (from-to)21-26
Number of pages6
JournalMicrosurgery
Volume27
Issue number1
DOIs
Publication statusPublished - 2007

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Mouth Floor
Free Tissue Flaps
Mouth Neoplasms
Bone and Bones
Forearm
Recurrence
Replantation
Mandible
Cosmetics
Mouth
Squamous Cell Carcinoma
Nitrogen
Tissue Donors
Neoplasm Metastasis
Morbidity
Costs and Cost Analysis

ASJC Scopus subject areas

  • Surgery

Cite this

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abstract = "Mandibular symphyseal resection requires composite reconstructions, often with unsatisfactory morphofunctional results. Seven patients with advanced squamous cell carcinoma of the floor of the mouth underwent block resection with immediate reconstruction, using the removed mandible treated with liquid nitrogen and covered with a free forearm flap. In all cases, the resection was radical and no major postoperative complications occurred. Two patients died in 6 months for distant metastases and regional recurrence. In the other 5 patients, no local recurrence occurred at a mean follow-up of 52 months (36-70). Immediate cosmetic and functional results were good. Of the 5 patients, 4 had late complications requiring further surgery. This technique of bone reimplantation produces no donor site morbidity, perfect immediate morphological result, and is of low cost. The free forearm flap is effective in sealing the oral cavity, though further clinical and experimental studies are necessary to reduce late local complications.",
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T1 - Composite reconstruction in advanced cancer of the mouth floor

T2 - Autogenous frozen-thawed mandibular bone and free flaps

AU - Calabrese, Luca

AU - Garusi, Cristina

AU - Giugliano, Gioacchino

AU - Ansarin, Mohssen

AU - Bruschini, Roberto

AU - Chiesa, Fausto

PY - 2007

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