Composition of the γ-chains of human fetal hemoglobin at birth and during intrauterine life

Giuseppe Saglio, Umberto Mazza, Clara Camaschella, Tullio Meloni, Maria Ausilia Ciocca-Vasino, Pier Giorgio Pich, Giuseppe Ricco

Research output: Contribution to journalArticle

Abstract

The composition of the γ-chains has been examined in 21 fetuses and premature babies and in 18 full-term newborns. Gγ/Aγ ratio was slightly higher in fetuses (0.81 ± 0.04 expressed as glycine residue at position 136) than in full-term newborns (0.73 ± 0.06), while the incidence and the percentage ofTγ-chains were clearly higher in the first group and overlap the values found in the Hb F from β-thalassemia homozygotes. On the basis of these data the authors hypothesize thatTγ-chains may be codified by a gene more active during intrauterine life than at birth. Possibly, their synthesis may be reactivated when high levels of Hb F are present during adult life, as in β-thalassemia.

Original languageEnglish
Pages (from-to)45-50
Number of pages6
JournalActa Haematologica
Volume62
Issue number1
DOIs
Publication statusPublished - 1979

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Keywords

  • <sup>T</sup>γ-chain
  • HbF
  • γ-Chain composition

ASJC Scopus subject areas

  • Hematology

Cite this

Saglio, G., Mazza, U., Camaschella, C., Meloni, T., Ciocca-Vasino, M. A., Pich, P. G., & Ricco, G. (1979). Composition of the γ-chains of human fetal hemoglobin at birth and during intrauterine life. Acta Haematologica, 62(1), 45-50. https://doi.org/10.1159/000207535