Compositions and methods for treatment of Parkinson's disease: A patent evaluation of WO2011/102847A1

Valerio Chiurchi, Mauro MacCarrone, Antonio Orlacchio

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The application (WO2011/102847A1) deals with methods useful for the treatment of Parkinson's disease (PD). Objective: It aims at producing mature and functional midbrain dopaminergic (mDA) neurons useful for the treatment of PD. Methods: mDA neurons were produced from neural progenitor cells or stem cells by activating both the Wnt-Lmx1a/Lmx1b and the SHH-FoxA2 signaling pathways. Results: The level of the proteins of these two synergic pathways is increased, as well as their biological activity. Conclusion: The invention provides a method for treating or preventing PD by increasing the level of at least one protein involved in an autoregulatory pathway, which is fundamental during mDA neurons differentiation.

Original languageEnglish
Pages (from-to)181-184
Number of pages4
JournalExpert Opinion on Therapeutic Patents
Volume22
Issue number2
DOIs
Publication statusPublished - Feb 2012

Keywords

  • Dopaminergic neurons
  • Neural progenitor cells
  • Parkinson's disease
  • Stem cells

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology

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