TY - JOUR
T1 - Compositions and methods for treatment of Parkinson's disease
T2 - A patent evaluation of WO2011/102847A1
AU - Chiurchi, Valerio
AU - MacCarrone, Mauro
AU - Orlacchio, Antonio
PY - 2012/2
Y1 - 2012/2
N2 - Background: The application (WO2011/102847A1) deals with methods useful for the treatment of Parkinson's disease (PD). Objective: It aims at producing mature and functional midbrain dopaminergic (mDA) neurons useful for the treatment of PD. Methods: mDA neurons were produced from neural progenitor cells or stem cells by activating both the Wnt-Lmx1a/Lmx1b and the SHH-FoxA2 signaling pathways. Results: The level of the proteins of these two synergic pathways is increased, as well as their biological activity. Conclusion: The invention provides a method for treating or preventing PD by increasing the level of at least one protein involved in an autoregulatory pathway, which is fundamental during mDA neurons differentiation.
AB - Background: The application (WO2011/102847A1) deals with methods useful for the treatment of Parkinson's disease (PD). Objective: It aims at producing mature and functional midbrain dopaminergic (mDA) neurons useful for the treatment of PD. Methods: mDA neurons were produced from neural progenitor cells or stem cells by activating both the Wnt-Lmx1a/Lmx1b and the SHH-FoxA2 signaling pathways. Results: The level of the proteins of these two synergic pathways is increased, as well as their biological activity. Conclusion: The invention provides a method for treating or preventing PD by increasing the level of at least one protein involved in an autoregulatory pathway, which is fundamental during mDA neurons differentiation.
KW - Dopaminergic neurons
KW - Neural progenitor cells
KW - Parkinson's disease
KW - Stem cells
UR - http://www.scopus.com/inward/record.url?scp=84857521368&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84857521368&partnerID=8YFLogxK
U2 - 10.1517/13543776.2012.655269
DO - 10.1517/13543776.2012.655269
M3 - Article
C2 - 22251081
AN - SCOPUS:84857521368
VL - 22
SP - 181
EP - 184
JO - Expert Opinion on Therapeutic Patents
JF - Expert Opinion on Therapeutic Patents
SN - 1354-3776
IS - 2
ER -