Compounds and methods for inhibiting mitotic progression

Daniele Fancelli

Research output: Contribution to journalArticlepeer-review


In this application, Millennium claims pyrimidoazepines, in particular N-aryl-(7-phenyl-5H-benzo[c]pyrimido[4,5-e]azepin-2-yl)-amino derivatives, as inhibitors of Aurora kinases. The claimed compounds display good potency (in most cases <100 nM) in the enzymatic bioassay for Aurora-A inhibition and are indicated to be useful for the treatment of cancer and other proliferative disorders.

Original languageEnglish
Pages (from-to)1179-1182
Number of pages4
JournalExpert Opinion on Therapeutic Patents
Issue number8
Publication statusPublished - Aug 2006


  • Antimitotic
  • Aurora kinase
  • Protein kinase inhibitor

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Pharmacology
  • Law


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