Compounds and methods for inhibiting mitotic progression

Daniele Fancelli

Research output: Contribution to journalArticle

Abstract

In this application, Millennium claims pyrimidoazepines, in particular N-aryl-(7-phenyl-5H-benzo[c]pyrimido[4,5-e]azepin-2-yl)-amino derivatives, as inhibitors of Aurora kinases. The claimed compounds display good potency (in most cases <100 nM) in the enzymatic bioassay for Aurora-A inhibition and are indicated to be useful for the treatment of cancer and other proliferative disorders.

Original languageEnglish
Pages (from-to)1179-1182
Number of pages4
JournalExpert Opinion on Therapeutic Patents
Volume16
Issue number8
DOIs
Publication statusPublished - Aug 2006

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Aurora Kinases
Biological Assay
cancer
Neoplasms

Keywords

  • Antimitotic
  • Aurora kinase
  • Protein kinase inhibitor

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Pharmacology
  • Law

Cite this

Compounds and methods for inhibiting mitotic progression. / Fancelli, Daniele.

In: Expert Opinion on Therapeutic Patents, Vol. 16, No. 8, 08.2006, p. 1179-1182.

Research output: Contribution to journalArticle

Fancelli, Daniele. / Compounds and methods for inhibiting mitotic progression. In: Expert Opinion on Therapeutic Patents. 2006 ; Vol. 16, No. 8. pp. 1179-1182.
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