Comprehensive nutritional assessment in short bowel syndrome with chronic renal failure on teduglutide therapy: A case report

Valeria Borioli, Emanuele Cereda, Federica Lobascio, Caterina Mengoli, Marilisa Caraccia, Anna Pagani, Nicola Aronico, Paolo Pedrazzoli, Antonio Di Sabatino, Riccardo Caccialanza

Research output: Contribution to journalArticle


We report the case of a 62-y-old woman with short bowel syndrome (SBS) and chronic renal failure, successfully treated with teduglutide, who underwent comprehensive systematic nutritional assessment including bioelectrical impedance vectorial analysis (BIVA). The patient did not tolerate the attempt of gradual suspension of parenteral nutrition (PN), bumping into the worsening of nutritional status and renal function. She was declared eligible for teduglutide, a glucagonlike peptide 2 analog that stimulates structural and functional intestinal adaptation and increases nutrient and fluid absorption. To date, there is no standardized nutritional management protocol for PN-dependent SBS patients treated with teduglutide. We here report our first 1-y follow-up data. The patient underwent comprehensive systematic nutritional assessment initially every 2 wk, then monthly. It included handgrip strength (HGS), blood tests (particularly serum creatinine, estimated glomerular filtration rate, urea, electrolytes, micronutrients, serum albumin), fluid intake, urine output, quality-of-life (QoL) evaluation, and BIVA, which estimates fat-free mass (FFM) and measures phase angle (PhA) and hydration status. At treatment initiation, the patient was on PN 3 d/wk. After 3 mo, she was weaned off PN. At 1 y, weight and serum albumin were reduced (–7.5 kg and –0.6 g/dL, respectively); FFM, PhA, and HGS slightly decreased; hydration status and renal function were preserved; and QoL subtly improved. No relevant clinical complications or metabolic imbalances occurred. The inclusion of BIVA in the comprehensive systematic nutritional assessment of SBS patients treated with teduglutide could be proposed for appropriate and safe management, particularly in the presence of renal impairment.

Original languageEnglish
Article number110720
Publication statusPublished - May 2020


  • Bioimpedance vectorial analysis
  • Nutritional assessment
  • Parenteral nutrition
  • Short bowel syndrome
  • Teduglutide

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Fingerprint Dive into the research topics of 'Comprehensive nutritional assessment in short bowel syndrome with chronic renal failure on teduglutide therapy: A case report'. Together they form a unique fingerprint.

  • Cite this