Comprehensive vertebral deformity and vertebral fracture assessment in clinical practice: Intra-and inter-reader agreement of a clinical workflow tool

Giuseppe Guglielmi, Jane Haslam, Francesco D'Errico, Peter Steiger, Michelangelo Nasuto

Research output: Contribution to journalArticlepeer-review

Abstract

STUDY DESIGN.: Study design randomized intra-and inter-reader reproducibility study. OBJECTIVE.: To evaluate reproducibility of quantitative morphometry (QM) and agreement of dichotomous fracture/no-fracture status on lateral spinal radiographs acquired during routine clinical practice using a clinical workflow tool. SUMMARY OF BACKGROUND DATA.: Several recent guidelines have underlined the importance of Genant semi-quantitative scoring and selective QM to confirm and grade suspected vertebral fractures in clinical practice. METHODS.: Thoracic and lumbar spine radiographs were acquired from 98 consecutive subjects (mean age, 60.1 ± 11.7 yr) attending the clinic for osteoporosis evaluation. For each subject, QM and Genant semi-quantitative scoring were performed on all evaluable vertebrae from L4 to T4 using a software workflow tool. A radiologist and an experienced radiographical technician performed 2 repeat reading sessions of the radiographs 12 months apart, blinded to each other's results; for the second read, the cases were anonymized and the order was randomized. RESULTS.: Inter-reader reproducibility results were 3.1% and 3.2% coefficient of variation (%) for heights, 0.030 and 0.031 root mean square standard deviation for height ratios. For intrareader reproducibility, these values were 2.2% and 3.5% coefficient of variation %; 0.023 and 0.034 root mean square standard deviation. Kappa score results for agreement of dichotomous fracture/no-fracture status were 0.67 and 0.72 (inter-rater) and 0.50 and 0.67 (intrarater). CONCLUSION.: The software assessed in this study is a reliable clinical tool that facilitates QM and Genant semi-quantitative scoring of the spine in routine clinical practice.

Original languageEnglish
JournalSpine
Volume38
Issue number26
DOIs
Publication statusPublished - Dec 15 2013

Keywords

  • computerassisted diagnosis
  • osteoporosis
  • radiography
  • reproducibility of results
  • spinal fractures

ASJC Scopus subject areas

  • Clinical Neurology
  • Orthopedics and Sports Medicine

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