Computational evaluation of yin yang 1 transcript levels in the spectrum of B-cell neoplasia

Massimo Libra, Elena Torrisi, Giancarlo Castellano, Ferdinando Nicoletti, Grazia Malaponte, Maria C. Mazzarino, Andrea Marconi, Lidia Proietti, Loredana Militello, Benjamin Bonavida, Franca Stivala, Silvana Canevari

Research output: Contribution to journalArticlepeer-review

Abstract

Non-Hodgkin's lymphomas (NHL) are a heterogeneous group of lymphoproliferative malignancies with variable patterns of behavior and response to treatments. Although many patients respond to conventional therapies, many relapse and become refractory to further treatments. Studies using B-NHL cell lines have shown that the Yin Yang 1 (YY1) transcription factor is implicated in the regulation of resistance to both chemotherapeutic and immunotherapeutic drugs. This study examined the involvement of YY1 in the spectrum of B-cell neoplasia. The transcript levels of YY1 were evaluated using two different data sets of publicly available microarrays for lymphoma tumor biopsy specimens. The findings revealed that YY1 expression levels increased in association with B-cell transformation, suggesting that YY1 may be involved in B-cell transformation and may give rise to Burkitt's lymphoma and diffuse large B-cell lymphoma.

Original languageEnglish
Pages (from-to)115-125
Number of pages11
JournalForum on Immunopathological Diseases and Therapeutics
Volume1
Issue number1-2
DOIs
Publication statusPublished - 2010

Keywords

  • Apoptosis
  • Non-hodgkin's lymphoma
  • Yin yang 1 (YY1)

ASJC Scopus subject areas

  • Genetics
  • Molecular Medicine
  • Biochemistry
  • Biotechnology

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