La tomografia computerizzata e i marker tumorali come alternative diagnostiche al second-look chirurgico nel trattamento dei tumori maligni dell'ovaio.

Translated title of the contribution: Computed tomography and tumor markers as diagnostic alternatives to second-look surgery in the treatment of malignant ovarian tumors

A. La Fianza, R. Campani, R. Dore, L. Babilonti, L. Torretta

Research output: Contribution to journalArticlepeer-review

Abstract

Advanced malignant ovarian cancers are treated, after initial surgery, with first-choice mono/polychemotherapy, the response to which is evaluated by means of second-look laparotomy. The poor prognostic value of second-look results, the incidence of false negatives, the lack of valuable second-choice therapies, and the high incidence of complications after repeated interventions, lead to the testing of diagnostic imaging modalities--especially CT and tumor markers (Ca 125 and Ca 15-3). To define their actual clinical value, CT and serum assays of Ca 125 and Ca 15-3 have been performed on 32 treated patients affected with ovarian cancers (stages II-IV), who were clinically free of disease. The results have been compared with second-look pathology, but especially with patient follow-up (min. 24 months). Second-look laparotomy yielded a high number of false negatives (9/22 = 41%); moreover, many important/severe complications were observed. Thus, its value appears to be questionable. CT exhibited high positive predictive value (76.9% over the 24-month follow-up); high for both Ca 125 and Ca 15-3 (100% respectively, at 24-month follow-up) thus, few false positives were observed. Moreover CT, having higher sensitivity (55.5%) than Ca 125 (11.5%) and Ca 15-3 (27.7%), has greater diagnostic capabilities, especially when the lesion is in extraperitoneal location.

Translated title of the contributionComputed tomography and tumor markers as diagnostic alternatives to second-look surgery in the treatment of malignant ovarian tumors
Original languageItalian
Pages (from-to)374-382
Number of pages9
JournalRadiologia Medica
Volume83
Issue number4
Publication statusPublished - Apr 1992

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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