Angiografia coronarica con tomografia computerizzata in individui asintomatici

Translated title of the contribution: Computed tomography coronary angiography in asymptomatic patients

E. Maffei, A. Palumbo, C. Martini, C. Tedeschi, T. Arcadi, L. La Grutta, R. Malagò, A. C. Weustink, N. R. Mollet, R. De Rosa, O. Catalano, I. Salamone, A. Blandino, M. Midiri, F. Cademartiri

Research output: Contribution to journalArticlepeer-review


Purpose: This study assessed the accuracy of computed tomography coronary angiography (CT-CA) for detecting significant coronary artery disease (CAD; ≥50% lumen reduction) in intermediate/high-risk asymptomatic patients. Materials and methods: A total of 183 consecutive asymptomatic individuals (92 men; mean age 54±11 years) with more than one major risk factor (obesity, hypertension, diabetes, hypercholesterolaemia, family history, smoking) and an inconclusive or nonfeasible noninvasive stress test result (stress electrocardiography, stress echocardiography, nuclear stress scintigraphy) underwent CT-CA in an outpatient setting. All patients underwent conventional coronary angiography (CAG) within 4 weeks. Data from CT-CA were compared with CAG regarding the presence of significant CAD (≥50% lumen reduction). Results: Mean calcium score was 177±432, mean heart rate during the CT-CA scan was 58±8 bpm and the prevalence (per-patient) of obstructive CAD was 19%. CT-CA showed single-vessel CAD in 9% of patients, two-vessel CAD in 9% and three-vessel CAD in 0%. Per-patient sensitivity, specificity, positive predictive value and negative predictive value of CT-CA were 100% (90-100), 98% (96-99), 97% (85-99), 100% (97-100), respectively. Positive and negative likelihood ratios were 151 and 0, respectively. Conclusions: CT-CA is an excellent noninvasive imaging modality for excluding significant CAD in intermediate/ high-risk asymptomatic patients with inconclusive or nonfeasible noninvasive stress test.

Translated title of the contributionComputed tomography coronary angiography in asymptomatic patients
Original languageItalian
Pages (from-to)1161-1173
Number of pages13
JournalRadiologia Medica
Issue number8
Publication statusPublished - Dec 2011

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)


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