Computed Tomography in Acute Severe Central Nervous System Complications in Children Treated for Cancer: Still a Useful Diagnostic Tool in the Emergency Setting

Emilia Ricci, Francesco Toni, Chiara Marra, Riccardo Masetti, Sayuri Porelli, Jessica Balducci, Andrea Pession, Duccio Maria Cordelli

Research output: Contribution to journalArticlepeer-review

Abstract

We retrospectively checked patients who underwent chemotherapy and/or hematopoietic stem cell transplantation from 2007 to 2016, in order to evaluate whether early computed tomography is useful in children treated for cancer with acute central nervous system complications. Out of a total sample of 443 patients, 52 children (11.7%) presented these complications. In the end, 31 patients were included, with a total of 33 events of central nervous system complications. The computed tomography was abnormal in 22 events (67%) and diagnostic for a specific complication in 20 events (61%), whereas it directly influenced the treatment in 16 events (48%). Computed tomography should be still considered a relevant diagnostic tool in the management of acute central nervous system complications in the emergency setting.

Original languageEnglish
JournalJournal of Child Neurology
DOIs
Publication statusAccepted/In press - 2020

Keywords

  • brain neuroimaging
  • chemotherapy neurotoxicities
  • stem cell transplantation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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