Computed tomography in nasopharyngeal carcinoma: Part II: Impact on survival

E. Cellai, P. Olmi, A. Chiavacci, G. Giannardi, R. Fargnoli, N. Villari, C. Fallai

Research output: Contribution to journalArticle

Abstract

Two hundred and seventeen consecutive patients affected by nasopharyngeal carcinoma (NPC) were treated with radiotherapy alone, with curative intent, from 1970 to 1985 at the Radiotherapy Unit of the University and Hospital of Florence. A group (A) of 111 patients staged with conventional clinical and radiological method was compared to a second group (B) of 106 patients who underwent CT staging before treatment. Group B showed better 5-year NED survival and local control; only the differences in local control were significant (p <0.01). As to primary control statistically significant differences were observed in T2 and T4 cases. We feel that CT could have contributed to the improvement, probably through a more reliable display of the primary extent and a more adequately planned radiotherapeutic treatment. With CT staging we could not increase our skills in prognostically separating stages according to UICC criteria (1978); in Group B only T2 patients presented significant differences in primary control when compared to T3 and T4 patients. However, a multivariate analysis of prognostic factors showed that nodal involvement, primarily, and histology, secondarily, were the most important factors, T stage showed a minor influence on prognosis.

Original languageEnglish
Pages (from-to)1177-1182
Number of pages6
JournalInternational Journal of Radiation Oncology Biology Physics
Volume19
Issue number5
DOIs
Publication statusPublished - 1990

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Keywords

  • CT-staging
  • Nasopharynx
  • Neoplasms
  • Radiotherapy

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation

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