Computed Tomography Measurement of Rib Cage Morphometry in Emphysema

Nicola Sverzellati, Davide Colombi, Giorgia Randi, Antonio Pavarani, Mario Silva, Simon L. Walsh, Massimo Pistolesi, Veronica Alfieri, Alfredo Chetta, Mauro Vaccarezza, Marco Vitale, Ugo Pastorino

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background:Factors determining the shape of the human rib cage are not completely understood. We aimed to quantify the contribution of anthropometric and COPD-related changes to rib cage variability in adult cigarette smokers.Methods:Rib cage diameters and areas (calculated from the inner surface of the rib cage) in 816 smokers with or without COPD, were evaluated at three anatomical levels using computed tomography (CT). CTs were analyzed with software, which allows quantification of total emphysema (emphysema%). The relationship between rib cage measurements and anthropometric factors, lung function indices, and %emphysema were tested using linear regression models.Results:A model that included gender, age, BMI, emphysema%, forced expiratory volume in one second (FEV1)%, and forced vital capacity (FVC)% fit best with the rib cage measurements (R2 = 64% for the rib cage area variation at the lower anatomical level). Gender had the biggest impact on rib cage diameter and area (105.3 cm2; 95% CI: 111.7 to 98.8 for male lower area). Emphysema% was responsible for an increase in size of upper and middle CT areas (up to 5.4 cm2; 95% CI: 3.0 to 7.8 for an emphysema increase of 5%). Lower rib cage areas decreased as FVC% decreased (5.1 cm2; 95% CI: 2.5 to 7.6 for 10 percentage points of FVC variation).Conclusions:This study demonstrates that simple CT measurements can predict rib cage morphometric variability and also highlight relationships between rib cage morphometry and emphysema.

Original languageEnglish
Article numbere68546
JournalPLoS One
Volume8
Issue number7
DOIs
Publication statusPublished - Jul 31 2013

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Emphysema
morphometry
computed tomography
ribs
Tomography
cages
Linear regression
Tobacco Products
Vital Capacity
Chronic Obstructive Pulmonary Disease
Linear Models
Rib Cage
cigarettes
gender
lung function
Forced Expiratory Volume
Software
Lung

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Sverzellati, N., Colombi, D., Randi, G., Pavarani, A., Silva, M., Walsh, S. L., ... Pastorino, U. (2013). Computed Tomography Measurement of Rib Cage Morphometry in Emphysema. PLoS One, 8(7), [e68546]. https://doi.org/10.1371/journal.pone.0068546

Computed Tomography Measurement of Rib Cage Morphometry in Emphysema. / Sverzellati, Nicola; Colombi, Davide; Randi, Giorgia; Pavarani, Antonio; Silva, Mario; Walsh, Simon L.; Pistolesi, Massimo; Alfieri, Veronica; Chetta, Alfredo; Vaccarezza, Mauro; Vitale, Marco; Pastorino, Ugo.

In: PLoS One, Vol. 8, No. 7, e68546, 31.07.2013.

Research output: Contribution to journalArticle

Sverzellati, N, Colombi, D, Randi, G, Pavarani, A, Silva, M, Walsh, SL, Pistolesi, M, Alfieri, V, Chetta, A, Vaccarezza, M, Vitale, M & Pastorino, U 2013, 'Computed Tomography Measurement of Rib Cage Morphometry in Emphysema', PLoS One, vol. 8, no. 7, e68546. https://doi.org/10.1371/journal.pone.0068546
Sverzellati N, Colombi D, Randi G, Pavarani A, Silva M, Walsh SL et al. Computed Tomography Measurement of Rib Cage Morphometry in Emphysema. PLoS One. 2013 Jul 31;8(7). e68546. https://doi.org/10.1371/journal.pone.0068546
Sverzellati, Nicola ; Colombi, Davide ; Randi, Giorgia ; Pavarani, Antonio ; Silva, Mario ; Walsh, Simon L. ; Pistolesi, Massimo ; Alfieri, Veronica ; Chetta, Alfredo ; Vaccarezza, Mauro ; Vitale, Marco ; Pastorino, Ugo. / Computed Tomography Measurement of Rib Cage Morphometry in Emphysema. In: PLoS One. 2013 ; Vol. 8, No. 7.
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