Computed tomography screening and lung cancer outcomes

Peter B. Bach, James R. Jett, Ugo Pastorino, Melvyn S. Tockman, Stephen J. Swensen, Colin B. Begg

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Context: Current and former smokers are currently being screened for lung cancer with computed tomography (CT), although there are limited data on the effect screening has on lung cancer outcomes. Randomized controlled trials assessing CT screening are currently under way. Objective: To assess whether screening may increase the frequency of lung cancer diagnosis and lung cancer resection or may reduce the risk of a diagnosis of advanced lung cancer or death from lung cancer. Design, Setting, and Participants: Longitudinal analysis of 3246 asymptomatic current or former smokers screened for lung cancer beginning in 1998 either at 1 of 2 academic medical centers in the United States or an academic medical center in Italy with follow-up for a median of 3.9 years. Intervention: Annual CT scans with comprehensive evaluation and treatment of detected nodules. Main Outcome Measures: Comparison of predicted with observed number of new lung cancer cases, lung cancer resections, advanced lung cancer cases, and deaths from lung cancer. Results: There were 144 individuals diagnosed with lung cancer compared with 44.5 expected cases (relative risk [RR], 3.2; 95% confidence interval [CI], 2.7-3.8; P

Original languageEnglish
Pages (from-to)953-961
Number of pages9
JournalJournal of the American Medical Association
Issue number9
Publication statusPublished - Mar 7 2007


ASJC Scopus subject areas

  • Medicine(all)

Cite this

Bach, P. B., Jett, J. R., Pastorino, U., Tockman, M. S., Swensen, S. J., & Begg, C. B. (2007). Computed tomography screening and lung cancer outcomes. Journal of the American Medical Association, 297(9), 953-961.