Computer analysis of saccadic eye movements: assessment of two different carbamazepine formulations

G. Tedeschi, G. Casucci, S. Allocca, R. Riva, A. Di Costanzo, A. Quattrone, A. Baruzzi, V. Bonavita

Research output: Contribution to journalArticlepeer-review

Abstract

The central effects of two different formulations of Carbamazepine (CBZ) have been examined by analysis of saccadic eye movements (SEM) in 6 healthy volunteers, who took part in a double-blind latin-square, placebo controlled study. Both a conventional- and a controlled-release formulation of CBZ produced a significant effect on peak saccadic velocity and saccade accuracy, but only the former affected saccade latency. Computer analysis of SEM confirmed it to be a highly sensitive method for detection of subclinical drug effects on the CNS.

Original languageEnglish
Pages (from-to)513-516
Number of pages4
JournalEuropean Journal of Clinical Pharmacology
Volume37
Issue number5
DOIs
Publication statusPublished - Sep 1989

Keywords

  • carbamazepine
  • saccadic eye movements
  • slow-release formulations

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

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