Computer analysis of saccadic eye movements: assessment of two different carbamazepine formulations

G. Tedeschi, G. Casucci, S. Allocca, R. Riva, A. Di Costanzo, A. Quattrone, A. Baruzzi, V. Bonavita

Research output: Contribution to journalArticle

Abstract

The central effects of two different formulations of Carbamazepine (CBZ) have been examined by analysis of saccadic eye movements (SEM) in 6 healthy volunteers, who took part in a double-blind latin-square, placebo controlled study. Both a conventional- and a controlled-release formulation of CBZ produced a significant effect on peak saccadic velocity and saccade accuracy, but only the former affected saccade latency. Computer analysis of SEM confirmed it to be a highly sensitive method for detection of subclinical drug effects on the CNS.

Original languageEnglish
Pages (from-to)513-516
Number of pages4
JournalEuropean Journal of Clinical Pharmacology
Volume37
Issue number5
DOIs
Publication statusPublished - Sep 1989

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Saccades
Carbamazepine
Healthy Volunteers
Placebos
Pharmaceutical Preparations

Keywords

  • carbamazepine
  • saccadic eye movements
  • slow-release formulations

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

Cite this

Computer analysis of saccadic eye movements : assessment of two different carbamazepine formulations. / Tedeschi, G.; Casucci, G.; Allocca, S.; Riva, R.; Di Costanzo, A.; Quattrone, A.; Baruzzi, A.; Bonavita, V.

In: European Journal of Clinical Pharmacology, Vol. 37, No. 5, 09.1989, p. 513-516.

Research output: Contribution to journalArticle

Tedeschi, G, Casucci, G, Allocca, S, Riva, R, Di Costanzo, A, Quattrone, A, Baruzzi, A & Bonavita, V 1989, 'Computer analysis of saccadic eye movements: assessment of two different carbamazepine formulations', European Journal of Clinical Pharmacology, vol. 37, no. 5, pp. 513-516. https://doi.org/10.1007/BF00558133
Tedeschi, G. ; Casucci, G. ; Allocca, S. ; Riva, R. ; Di Costanzo, A. ; Quattrone, A. ; Baruzzi, A. ; Bonavita, V. / Computer analysis of saccadic eye movements : assessment of two different carbamazepine formulations. In: European Journal of Clinical Pharmacology. 1989 ; Vol. 37, No. 5. pp. 513-516.
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