Computerized three-dimensional reconstruction of the developing blood-brain barrier

M. Bertossi, D. Ribatti, B. Nico, D. Virgintino, L. Mancini, L. Roncali

Research output: Contribution to journalArticle

Abstract

Computer-aided techniques for three-dimensional reconstruction of images were employed in a morphological and morphometrical study of blood-brain barrier (BBB) development in the micro-vasculature of the chick embryo optic tectum. The method proved very useful for understanding the spatial relationships between BBB vascular and perivascular components, and of their modifications during embryonic life. The results indicate that the perivascular astrocytic endfeet, the main periendothelial components of the BBB, appear on the 14th incubation day and form an almost continuous perivascular envelope at hatching time.

Original languageEnglish
Pages (from-to)48-51
Number of pages4
JournalActa Neuropathologica
Volume79
Issue number1
DOIs
Publication statusPublished - Oct 1989

Keywords

  • Blood-brain barrier
  • Chick embryo
  • Optic tectum
  • Three-dimensional reconstruction

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pathology and Forensic Medicine
  • Clinical Neurology

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  • Cite this

    Bertossi, M., Ribatti, D., Nico, B., Virgintino, D., Mancini, L., & Roncali, L. (1989). Computerized three-dimensional reconstruction of the developing blood-brain barrier. Acta Neuropathologica, 79(1), 48-51. https://doi.org/10.1007/BF00308957