Concanavalin A induces a T-cell dependent activation of human tonsil B cells in vitro

A. Vitiello, L. Nespoli, A. Lanzavecchia, R. Maccario, A. G. Ugazio

Research output: Contribution to journalArticle

Abstract

Tonsillar lymphocytes cultured for 7 days in serum-supplemented RPMI-1640 medium were stimulated with Con A or PWM. IgM production was assessed by a hemagglutination inhibition assay. IgM was produced after Con A as well as PWM stimulation. Our data show that T-cell irradiation and/or addition of small numbers of T cells to the responding B-cell population facilitate(s) IgM synthesis. In particular in Con A-stimulated cultures the T-cell number is critical in regulating the appearance of suppressor effects. The results are discussed in terms of the various subpopulations possibly involved in the response to these mitogens.

Original languageEnglish
Pages (from-to)215-223
Number of pages9
JournalThymus
Volume1
Issue number4-5
Publication statusPublished - 1980

ASJC Scopus subject areas

  • Immunology

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