Concealed arrhythmogenic syndromes

The hidden substrate of idiopathic ventricular fibrillation?

Silvia G. Priori, Carlo Napolitano, Massimiliano Grillo

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

In ∼6-10% of survivors of cardiac arrest no cardiac abnormality can be identified despite extensive clinical evaluation. Autopsy data confirm that in a similar percentage of victims of sudden death no structural heart disease can be identified at post mortem evaluation. Occurrence of cardiac arrest in the absence of a substrate is defined 'idiopathic ventricular fibrillation' thus admitting that the cause for the arrhythmic event has remained unknown. We present data supporting the hypothesis that incompletely penetrant genetic defects may underlie at least some of these unexplained deaths.

Original languageEnglish
Pages (from-to)218-223
Number of pages6
JournalCardiovascular Research
Volume50
Issue number2
DOIs
Publication statusPublished - 2001

Fingerprint

Heart Arrest
Sudden Death
Survivors
Autopsy
Heart Diseases
Paroxysmal ventricular fibrillation

Keywords

  • Arrhythmia (mechanisms)
  • Long QT syndrome
  • Sudden death
  • Ventricular arrhythmias

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Concealed arrhythmogenic syndromes : The hidden substrate of idiopathic ventricular fibrillation? / Priori, Silvia G.; Napolitano, Carlo; Grillo, Massimiliano.

In: Cardiovascular Research, Vol. 50, No. 2, 2001, p. 218-223.

Research output: Contribution to journalArticle

@article{460770891ecf495996c3e257c10d762c,
title = "Concealed arrhythmogenic syndromes: The hidden substrate of idiopathic ventricular fibrillation?",
abstract = "In ∼6-10{\%} of survivors of cardiac arrest no cardiac abnormality can be identified despite extensive clinical evaluation. Autopsy data confirm that in a similar percentage of victims of sudden death no structural heart disease can be identified at post mortem evaluation. Occurrence of cardiac arrest in the absence of a substrate is defined 'idiopathic ventricular fibrillation' thus admitting that the cause for the arrhythmic event has remained unknown. We present data supporting the hypothesis that incompletely penetrant genetic defects may underlie at least some of these unexplained deaths.",
keywords = "Arrhythmia (mechanisms), Long QT syndrome, Sudden death, Ventricular arrhythmias",
author = "Priori, {Silvia G.} and Carlo Napolitano and Massimiliano Grillo",
year = "2001",
doi = "10.1016/S0008-6363(01)00224-3",
language = "English",
volume = "50",
pages = "218--223",
journal = "Cardiovascular Research",
issn = "0008-6363",
publisher = "Oxford University Press",
number = "2",

}

TY - JOUR

T1 - Concealed arrhythmogenic syndromes

T2 - The hidden substrate of idiopathic ventricular fibrillation?

AU - Priori, Silvia G.

AU - Napolitano, Carlo

AU - Grillo, Massimiliano

PY - 2001

Y1 - 2001

N2 - In ∼6-10% of survivors of cardiac arrest no cardiac abnormality can be identified despite extensive clinical evaluation. Autopsy data confirm that in a similar percentage of victims of sudden death no structural heart disease can be identified at post mortem evaluation. Occurrence of cardiac arrest in the absence of a substrate is defined 'idiopathic ventricular fibrillation' thus admitting that the cause for the arrhythmic event has remained unknown. We present data supporting the hypothesis that incompletely penetrant genetic defects may underlie at least some of these unexplained deaths.

AB - In ∼6-10% of survivors of cardiac arrest no cardiac abnormality can be identified despite extensive clinical evaluation. Autopsy data confirm that in a similar percentage of victims of sudden death no structural heart disease can be identified at post mortem evaluation. Occurrence of cardiac arrest in the absence of a substrate is defined 'idiopathic ventricular fibrillation' thus admitting that the cause for the arrhythmic event has remained unknown. We present data supporting the hypothesis that incompletely penetrant genetic defects may underlie at least some of these unexplained deaths.

KW - Arrhythmia (mechanisms)

KW - Long QT syndrome

KW - Sudden death

KW - Ventricular arrhythmias

UR - http://www.scopus.com/inward/record.url?scp=0035028477&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035028477&partnerID=8YFLogxK

U2 - 10.1016/S0008-6363(01)00224-3

DO - 10.1016/S0008-6363(01)00224-3

M3 - Article

VL - 50

SP - 218

EP - 223

JO - Cardiovascular Research

JF - Cardiovascular Research

SN - 0008-6363

IS - 2

ER -