Concentration- and time-dependent effects of γ-linolenic acid supplementation to tumor cells in culture

S. Hrelia, A. Pession, R. Buda, A. Lorenzini, D. F. Horrobin, P. L. Biagi, A. Bordoni

Research output: Contribution to journalArticle

Abstract

Gamma-linolenic acid (GLA) supplemented to neuroblastoma SK-N-BE, tubal carcinoma TG and colon carcinoma SW-620 cells was incorporated into phospholipids in all the cell lines (although to different extents), in a concentration- and time-dependent manner. All the cell lines were able to metabolize GLA to arachidonic acid, SK-N-BE being the most active. Supplementation with low GLA concentrations for short periods was not sufficient to impair cell proliferation; only higher amounts of GLA had an anti-proliferative effect also in short times. In these conditions, the antiproliferative effect of GLA is probably due to cellular dysfunction caused by fatty acid modifications.

Original languageEnglish
Pages (from-to)235-241
Number of pages7
JournalProstaglandins, Leukotrienes and Essential Fatty Acids
Volume60
Issue number4
DOIs
Publication statusPublished - Apr 1999

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Endocrinology, Diabetes and Metabolism

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