Concentration of fibronectin in plasma of tumor-bearing mice and synthesis by Ehrlich ascites tumor cells

L. Zardi, C. Cecconi, O. Barbieri, B. Carnemolla, M. Picca, L. Santi

Research output: Contribution to journalArticle

Abstract

In the present paper we have studied: (a) the concentration of fibronectin (FN) in plasma and in ascitic fluid of mice at different times after inoculation of Ehrlich ascites tumor cells; (b) the ability of Ehrlich ascites cells to synthesize and release FN; and (c) the localization of FN in Ehrlich ascites cells by immunofluorescence microscopy. It was found that (a) 4 to 5 days after inoculation of the tumor, the plasma concentration of FNA was significantly higher [1.7 ± 0.07% (SE) of total plasma protein] than that in the normal control mice (0.8 ± 0.035); (b) FN is present in the ascitic fluid in all phases of tumor growth; (c) Ehrlich ascites cells cultured in vitro synthesize and release large amounts of FN in the culture medium; and (d) only about 1 to 2% of the tumor cells show a very small amount of FN, and this mostly in the area of cell-cell contact.

Original languageEnglish
Pages (from-to)3774-3779
Number of pages6
JournalCancer Research
Volume39
Issue number9
Publication statusPublished - 1979

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Zardi, L., Cecconi, C., Barbieri, O., Carnemolla, B., Picca, M., & Santi, L. (1979). Concentration of fibronectin in plasma of tumor-bearing mice and synthesis by Ehrlich ascites tumor cells. Cancer Research, 39(9), 3774-3779.