Concentrations of flurithromycin in serum and tonsils

G. B. Galioto, E. Mevio, P. Galioto, G. Zanuso, A. M. Lepore

Research output: Contribution to journalArticle

Abstract

The concentrations of flurithromycin in serum and palatine tonsils of eleven adult male patients undergoing tonsillectomy were determined. Each patient received 500 mg t.i.d., in all ten doses, before tonsillectomy. Flurithromycin concentrations were measured by a microbiological method. Mean serum levels (± SE) were 0.72 μg/ml (± 0.19) after 8 h from the 9th dose and 0.67 μg/ml (± 0.13) after 4 h from the 10th dose. Average concentrations (± SE) in tonsils were: 1.43 ± 0.20 μg/g (right) and 1.32 ± 0.21 (left) 4 h after the last administration. Therefore, the mean tissue/serum ratio was about 2:1. These results indicate a good diffusion of flurithromycin from serum to tonsillar tissue.

Original languageEnglish
Pages (from-to)126-128
Number of pages3
JournalInternational Journal of Clinical Pharmacology Therapy and Toxicology
Volume27
Issue number3
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Toxicology

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