Abstract
The concentrations of flurithromycin in serum and palatine tonsils of eleven adult male patients undergoing tonsillectomy were determined. Each patient received 500 mg t.i.d., in all ten doses, before tonsillectomy. Flurithromycin concentrations were measured by a microbiological method. Mean serum levels (± SE) were 0.72 μg/ml (± 0.19) after 8 h from the 9th dose and 0.67 μg/ml (± 0.13) after 4 h from the 10th dose. Average concentrations (± SE) in tonsils were: 1.43 ± 0.20 μg/g (right) and 1.32 ± 0.21 (left) 4 h after the last administration. Therefore, the mean tissue/serum ratio was about 2:1. These results indicate a good diffusion of flurithromycin from serum to tonsillar tissue.
| Original language | English |
|---|---|
| Pages (from-to) | 126-128 |
| Number of pages | 3 |
| Journal | International Journal of Clinical Pharmacology Therapy and Toxicology |
| Volume | 27 |
| Issue number | 3 |
| Publication status | Published - 1989 |
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ASJC Scopus subject areas
- Pharmacology (medical)
- Toxicology
Cite this
Concentrations of flurithromycin in serum and tonsils. / Galioto, G. B.; Mevio, E.; Galioto, P.; Zanuso, G.; Lepore, A. M.
In: International Journal of Clinical Pharmacology Therapy and Toxicology, Vol. 27, No. 3, 1989, p. 126-128.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Concentrations of flurithromycin in serum and tonsils
AU - Galioto, G. B.
AU - Mevio, E.
AU - Galioto, P.
AU - Zanuso, G.
AU - Lepore, A. M.
PY - 1989
Y1 - 1989
N2 - The concentrations of flurithromycin in serum and palatine tonsils of eleven adult male patients undergoing tonsillectomy were determined. Each patient received 500 mg t.i.d., in all ten doses, before tonsillectomy. Flurithromycin concentrations were measured by a microbiological method. Mean serum levels (± SE) were 0.72 μg/ml (± 0.19) after 8 h from the 9th dose and 0.67 μg/ml (± 0.13) after 4 h from the 10th dose. Average concentrations (± SE) in tonsils were: 1.43 ± 0.20 μg/g (right) and 1.32 ± 0.21 (left) 4 h after the last administration. Therefore, the mean tissue/serum ratio was about 2:1. These results indicate a good diffusion of flurithromycin from serum to tonsillar tissue.
AB - The concentrations of flurithromycin in serum and palatine tonsils of eleven adult male patients undergoing tonsillectomy were determined. Each patient received 500 mg t.i.d., in all ten doses, before tonsillectomy. Flurithromycin concentrations were measured by a microbiological method. Mean serum levels (± SE) were 0.72 μg/ml (± 0.19) after 8 h from the 9th dose and 0.67 μg/ml (± 0.13) after 4 h from the 10th dose. Average concentrations (± SE) in tonsils were: 1.43 ± 0.20 μg/g (right) and 1.32 ± 0.21 (left) 4 h after the last administration. Therefore, the mean tissue/serum ratio was about 2:1. These results indicate a good diffusion of flurithromycin from serum to tonsillar tissue.
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UR - http://www.scopus.com/inward/citedby.url?scp=0024511514&partnerID=8YFLogxK
M3 - Article
C2 - 2722307
AN - SCOPUS:0024511514
VL - 27
SP - 126
EP - 128
JO - International Journal of Clinical Pharmacology and Therapeutics
JF - International Journal of Clinical Pharmacology and Therapeutics
SN - 0174-4879
IS - 3
ER -