Concentrations of polychlorinated dibenzodioxins, polychlorodibenzofurans, and polychlorobiphenyls in women of reproductive age in Italy: A human biomonitoring study

Anna Maria Ingelido, Vittorio Abate, Annalisa Abballe, Fulvia Lucia Albano, Tatiana Battista, Valter Carraro, Michele Conversano, Rosa Corvetti, Silvia De Luca, Silva Franchini, Anna Rita Fulgenzi, Laura Giambanco, Nicola Iacovella, Anna Laura Iamiceli, Antonio Maiorana, Francesco Maneschi, Valentina Marra, Flavia Pirola, Maria Grazia Porpora, Enrico ProcopioNicola Suma, Silvia Valentini, Luisa Valsenti, Valerio Vecchiè, Elena De Felip

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background Polychlorinated dibenzodioxins (PCDDs), polychlorodibenzofurans (PCDFs), and polychlorobiphenyls (PCBs) are persistent organic pollutants that represent a major concern for women of reproductive age because of the neurodevelopmental effects associated to perinatal exposure. Objectives This study was aimed at characterizing exposure of women of reproductive age to PCDDs, PCDFs, and PCBs as a function of residence in different Italian Regions, in areas at presumable different environmental contamination and human exposure to these pollutants. Methods Study participants were enrolled in 2011–2012 in 6 Italian Regions representative of Northern, Central and Southern Italy; in each region, areas at presumed different exposure (rural, urban and industrial) were selected for enrolment. Each participant provided a serum sample for the analysis of PCDDs, PCDFs and PCBs. Results Median concentrations of PCDDs + PCDFs, DL-PCBs, NDL6-PCBs and NDL9-PCBs in serum samples were respectively 6.0 and 3.5 pgWHO-TE05/g fat, and 75 and 93 ng/g fat. Age was the variable that most affected median serum concentrations. Age adjusted concentrations were found significantly different between geographical zones: women from Northern Italy showed the highest values, followed by Central and Southern Italy. PCDDs + PCDFs concentrations were significantly higher in the group of women residing in industrial areas compared to the group residing in rural areas. A clear diminishing temporal trend was observed compared to levels reported in previous studies. Conclusions This study produced the largest dataset on serum concentrations of PCDDs, PCDFs and PCBs in women of childbearing age in Italy. Results confirmed that environmental and lifestyle factors may influence exposure to these contaminants and thereby the body burden. The observed marked temporal decline in body burden during three decades is in agreement with the general trend observed worldwide.

Original languageEnglish
Pages (from-to)378-386
Number of pages9
JournalInternational Journal of Hygiene and Environmental Health
Volume220
Issue number2
DOIs
Publication statusPublished - Apr 1 2017

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Environmental Monitoring
Italy
Body Burden
Serum
Fats
Polychlorinated Dibenzodioxins
polychlorodibenzofuran
Life Style

Keywords

  • Human biomonitoring
  • Italy
  • PCBs
  • PCDDs
  • PCDFs
  • Women

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Concentrations of polychlorinated dibenzodioxins, polychlorodibenzofurans, and polychlorobiphenyls in women of reproductive age in Italy : A human biomonitoring study. / Ingelido, Anna Maria; Abate, Vittorio; Abballe, Annalisa; Albano, Fulvia Lucia; Battista, Tatiana; Carraro, Valter; Conversano, Michele; Corvetti, Rosa; De Luca, Silvia; Franchini, Silva; Fulgenzi, Anna Rita; Giambanco, Laura; Iacovella, Nicola; Iamiceli, Anna Laura; Maiorana, Antonio; Maneschi, Francesco; Marra, Valentina; Pirola, Flavia; Porpora, Maria Grazia; Procopio, Enrico; Suma, Nicola; Valentini, Silvia; Valsenti, Luisa; Vecchiè, Valerio; De Felip, Elena.

In: International Journal of Hygiene and Environmental Health, Vol. 220, No. 2, 01.04.2017, p. 378-386.

Research output: Contribution to journalArticle

Ingelido, Anna Maria ; Abate, Vittorio ; Abballe, Annalisa ; Albano, Fulvia Lucia ; Battista, Tatiana ; Carraro, Valter ; Conversano, Michele ; Corvetti, Rosa ; De Luca, Silvia ; Franchini, Silva ; Fulgenzi, Anna Rita ; Giambanco, Laura ; Iacovella, Nicola ; Iamiceli, Anna Laura ; Maiorana, Antonio ; Maneschi, Francesco ; Marra, Valentina ; Pirola, Flavia ; Porpora, Maria Grazia ; Procopio, Enrico ; Suma, Nicola ; Valentini, Silvia ; Valsenti, Luisa ; Vecchiè, Valerio ; De Felip, Elena. / Concentrations of polychlorinated dibenzodioxins, polychlorodibenzofurans, and polychlorobiphenyls in women of reproductive age in Italy : A human biomonitoring study. In: International Journal of Hygiene and Environmental Health. 2017 ; Vol. 220, No. 2. pp. 378-386.
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abstract = "Background Polychlorinated dibenzodioxins (PCDDs), polychlorodibenzofurans (PCDFs), and polychlorobiphenyls (PCBs) are persistent organic pollutants that represent a major concern for women of reproductive age because of the neurodevelopmental effects associated to perinatal exposure. Objectives This study was aimed at characterizing exposure of women of reproductive age to PCDDs, PCDFs, and PCBs as a function of residence in different Italian Regions, in areas at presumable different environmental contamination and human exposure to these pollutants. Methods Study participants were enrolled in 2011–2012 in 6 Italian Regions representative of Northern, Central and Southern Italy; in each region, areas at presumed different exposure (rural, urban and industrial) were selected for enrolment. Each participant provided a serum sample for the analysis of PCDDs, PCDFs and PCBs. Results Median concentrations of PCDDs + PCDFs, DL-PCBs, NDL6-PCBs and NDL9-PCBs in serum samples were respectively 6.0 and 3.5 pgWHO-TE05/g fat, and 75 and 93 ng/g fat. Age was the variable that most affected median serum concentrations. Age adjusted concentrations were found significantly different between geographical zones: women from Northern Italy showed the highest values, followed by Central and Southern Italy. PCDDs + PCDFs concentrations were significantly higher in the group of women residing in industrial areas compared to the group residing in rural areas. A clear diminishing temporal trend was observed compared to levels reported in previous studies. Conclusions This study produced the largest dataset on serum concentrations of PCDDs, PCDFs and PCBs in women of childbearing age in Italy. Results confirmed that environmental and lifestyle factors may influence exposure to these contaminants and thereby the body burden. The observed marked temporal decline in body burden during three decades is in agreement with the general trend observed worldwide.",
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T1 - Concentrations of polychlorinated dibenzodioxins, polychlorodibenzofurans, and polychlorobiphenyls in women of reproductive age in Italy

T2 - A human biomonitoring study

AU - Ingelido, Anna Maria

AU - Abate, Vittorio

AU - Abballe, Annalisa

AU - Albano, Fulvia Lucia

AU - Battista, Tatiana

AU - Carraro, Valter

AU - Conversano, Michele

AU - Corvetti, Rosa

AU - De Luca, Silvia

AU - Franchini, Silva

AU - Fulgenzi, Anna Rita

AU - Giambanco, Laura

AU - Iacovella, Nicola

AU - Iamiceli, Anna Laura

AU - Maiorana, Antonio

AU - Maneschi, Francesco

AU - Marra, Valentina

AU - Pirola, Flavia

AU - Porpora, Maria Grazia

AU - Procopio, Enrico

AU - Suma, Nicola

AU - Valentini, Silvia

AU - Valsenti, Luisa

AU - Vecchiè, Valerio

AU - De Felip, Elena

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Background Polychlorinated dibenzodioxins (PCDDs), polychlorodibenzofurans (PCDFs), and polychlorobiphenyls (PCBs) are persistent organic pollutants that represent a major concern for women of reproductive age because of the neurodevelopmental effects associated to perinatal exposure. Objectives This study was aimed at characterizing exposure of women of reproductive age to PCDDs, PCDFs, and PCBs as a function of residence in different Italian Regions, in areas at presumable different environmental contamination and human exposure to these pollutants. Methods Study participants were enrolled in 2011–2012 in 6 Italian Regions representative of Northern, Central and Southern Italy; in each region, areas at presumed different exposure (rural, urban and industrial) were selected for enrolment. Each participant provided a serum sample for the analysis of PCDDs, PCDFs and PCBs. Results Median concentrations of PCDDs + PCDFs, DL-PCBs, NDL6-PCBs and NDL9-PCBs in serum samples were respectively 6.0 and 3.5 pgWHO-TE05/g fat, and 75 and 93 ng/g fat. Age was the variable that most affected median serum concentrations. Age adjusted concentrations were found significantly different between geographical zones: women from Northern Italy showed the highest values, followed by Central and Southern Italy. PCDDs + PCDFs concentrations were significantly higher in the group of women residing in industrial areas compared to the group residing in rural areas. A clear diminishing temporal trend was observed compared to levels reported in previous studies. Conclusions This study produced the largest dataset on serum concentrations of PCDDs, PCDFs and PCBs in women of childbearing age in Italy. Results confirmed that environmental and lifestyle factors may influence exposure to these contaminants and thereby the body burden. The observed marked temporal decline in body burden during three decades is in agreement with the general trend observed worldwide.

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KW - Human biomonitoring

KW - Italy

KW - PCBs

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KW - Women

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