Concentrations of VP16 and VM26 in human brain tumors

M. Zucchetti, C. Rossi, R. Knerich, M. G. Donelli, G. Butti, V. Silvani, P. Gaetani, M. D'Incalci

Research output: Contribution to journalArticlepeer-review

Abstract

VP16 and VM26 were determined by high pressure liquid chromatography in intracerebral tumors, adjacent normal brain tissue, plasma and CSF samples from 24 patients given the two drugs before surgical resection of the tumor. The drugs were administered at doses of 100-150 mg/m 2 as a 1-hour i.v. infusion, between 1.5 and 12 hours before surgery. Concentrations of VP16 ranged between 1.05 and 3.28 μg/g in tumors in the series of patients who received the drug 15-3 hours before surgery and between <0.05 and 1.12 μg/g in four patients who received the drug 9-13 hours before surgery. Tumor concentrations of VM26 also varied, ranging from <0.05 to 1.68 μg/g between 1.5 and 12 hours before surgery. VP16 and VM26 in the apparently normal brain tissue surrounding the tumor were low or undetectable except in one patient who had received radiotherapy, in whom we found 3.1 μg/g.

Original languageEnglish
Pages (from-to)63-66
Number of pages4
JournalAnnals of Oncology
Volume2
Issue number1
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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