Concise survey of Staphylococcus aureus virulence factors that promote adhesion and damage to peri-implant tissues

Carla Renata Arciola, Livia Visai, Francesca Testoni, Susanna Arciola, Davide Campoccia, Pietro Speziale, Lucio Montanaro

Research output: Contribution to journalArticlepeer-review

Abstract

Staphylococcus aureus is the leading cause of infection in orthopedic implants and of osteomyelitis consequent to it. Here we focus on the wide array of virulence factors that endow S. aureus with its abilities to colonize peri-prosthesis tissues and to attack and damage them. Following an infective strategy orchestrated by agr locus, Staphylococcus aureus first deploys virulence factors for adhesion to the prosthesis and peri-prosthesis tissues and then launches its attack by delivering destructive factors.

Original languageEnglish
Pages (from-to)771-780
Number of pages10
JournalInternational Journal of Artificial Organs
Volume34
Issue number9
DOIs
Publication statusPublished - Sep 2011

Keywords

  • Agr
  • Biofilm
  • Implant infection
  • MSCRAMMs
  • Staphylococcus aureus
  • Toxins

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Bioengineering
  • Medicine (miscellaneous)

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