Radio-chemioterapia concomitante con regimi a base di antracicline nel trattamento adiuvante del carcinoma mammario: Esperienza di un singolo centro

Translated title of the contribution: Concomitant adjuvant chemo-radiation therapy with anthracyclinebased regimens in breast cancer: A single centre experience

L. Livi, I. Meattini, V. Scotti, C. Saieva, G. Simontacchi, L. Marrazzo, C. Franzese, S. Cassani, F. Paiar, V. Di Cataldo, J. Nori, L. Jose Sanchez, S. Bianchi, L. Cataliotti, G. Biti

Research output: Contribution to journalArticle

Abstract

Purpose: This study was done to evaluate the toxicity related to concurrent radiotherapy and anthracycline (AC)-based chemotherapy in the adjuvant treatment of early breast cancer and to investigate the impact of treatment interruptions and the feasibility of this uncommon therapeutic approach. Materials and methods: From September 2002 to December 2007, 60 patients were treated at our Centre. The mean age at presentation was 48.5 (range 38-64) years. All patients underwent conservative surgery, and radiotherapy to the entire breast (mean dose 50 Gy; range 46-52 Gy). AC-based regimens consisted of four cycles of AC (doxorubicin plus cyclophosphamide) or four cycles of epirubicin (EPI) followed by four courses of cyclophosphamide, methotrexate and 5-fluorouracil (CMF). Results: Concomitant treatment caused acute skin G3 toxicity in 8.9% of patients and one case of G4 toxicity (1.7%). Concerning cardiac assessment, six of the 56 evaluable patients (10.7%) developed an asymptomatic decline of left ventricular ejection fraction >10% and

Translated title of the contributionConcomitant adjuvant chemo-radiation therapy with anthracyclinebased regimens in breast cancer: A single centre experience
Original languageItalian
Pages (from-to)1050-1058
Number of pages9
JournalRadiologia Medica
Volume116
Issue number7
DOIs
Publication statusPublished - Oct 2011

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

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    Livi, L., Meattini, I., Scotti, V., Saieva, C., Simontacchi, G., Marrazzo, L., Franzese, C., Cassani, S., Paiar, F., Di Cataldo, V., Nori, J., Jose Sanchez, L., Bianchi, S., Cataliotti, L., & Biti, G. (2011). Radio-chemioterapia concomitante con regimi a base di antracicline nel trattamento adiuvante del carcinoma mammario: Esperienza di un singolo centro. Radiologia Medica, 116(7), 1050-1058. https://doi.org/10.1007/s11547-011-0652-2