Concomitant malignant mesothelioma of the pleura, peritoneum, and tunica vaginalis testis

Valeria Ascoli, Francesco Facciolo, Siavash Rahimi, Caterina Carnovale Scalzo, Francesco Nardi

Research output: Contribution to journalArticle

Abstract

We describe the cytohistological, immunohistochemical and ultrastructural findings in a 55-yr-old-man with history of asbestos exposure and diffuse malignant mesothelioma (DMM) of the pleura, peritoneum, and tunica vaginalis presenting with chest pain and scrotal swelling. Pleural fine-needle aspiration (FNA) revealed mesenchymal elements and spindle-shaped epithelial- like cells, while biopsy showed pure sarcomatous tumor invading lung parenchyma. In both samples tumor cells coexpressed cytokeratin and vimentin. Peritoneal and hydrocele effusions contained aggregates of malignant mesothelial cells. Electron microscopy showed intermediate filaments, rare desmosomes and sparse microvilli. Morphological findings were consistent with a DMM, with a biphasic pattern in the pleura and an epithelial one in the peritoneum and tunica vaginalis. Although the possibility of a multicentric origin cannot be ruled out, clinical chronologic sequence suggests that the pleura was the primary involved site, followed by spread to peritoneum and tunica vaginalis.

Original languageEnglish
Pages (from-to)243-248
Number of pages6
JournalDiagnostic Cytopathology
Volume14
Issue number3
DOIs
Publication statusPublished - May 1996

    Fingerprint

Keywords

  • Cytokeratin
  • Effusion
  • Electron microscopy
  • Fine-needle aspiration biopsy
  • Sarcomatoid-mesothelioma
  • Vimentin

ASJC Scopus subject areas

  • Anatomy

Cite this