TY - JOUR
T1 - Concomitant malignant mesothelioma of the pleura, peritoneum, and tunica vaginalis testis
AU - Ascoli, Valeria
AU - Facciolo, Francesco
AU - Rahimi, Siavash
AU - Scalzo, Caterina Carnovale
AU - Nardi, Francesco
PY - 1996/5
Y1 - 1996/5
N2 - We describe the cytohistological, immunohistochemical and ultrastructural findings in a 55-yr-old-man with history of asbestos exposure and diffuse malignant mesothelioma (DMM) of the pleura, peritoneum, and tunica vaginalis presenting with chest pain and scrotal swelling. Pleural fine-needle aspiration (FNA) revealed mesenchymal elements and spindle-shaped epithelial- like cells, while biopsy showed pure sarcomatous tumor invading lung parenchyma. In both samples tumor cells coexpressed cytokeratin and vimentin. Peritoneal and hydrocele effusions contained aggregates of malignant mesothelial cells. Electron microscopy showed intermediate filaments, rare desmosomes and sparse microvilli. Morphological findings were consistent with a DMM, with a biphasic pattern in the pleura and an epithelial one in the peritoneum and tunica vaginalis. Although the possibility of a multicentric origin cannot be ruled out, clinical chronologic sequence suggests that the pleura was the primary involved site, followed by spread to peritoneum and tunica vaginalis.
AB - We describe the cytohistological, immunohistochemical and ultrastructural findings in a 55-yr-old-man with history of asbestos exposure and diffuse malignant mesothelioma (DMM) of the pleura, peritoneum, and tunica vaginalis presenting with chest pain and scrotal swelling. Pleural fine-needle aspiration (FNA) revealed mesenchymal elements and spindle-shaped epithelial- like cells, while biopsy showed pure sarcomatous tumor invading lung parenchyma. In both samples tumor cells coexpressed cytokeratin and vimentin. Peritoneal and hydrocele effusions contained aggregates of malignant mesothelial cells. Electron microscopy showed intermediate filaments, rare desmosomes and sparse microvilli. Morphological findings were consistent with a DMM, with a biphasic pattern in the pleura and an epithelial one in the peritoneum and tunica vaginalis. Although the possibility of a multicentric origin cannot be ruled out, clinical chronologic sequence suggests that the pleura was the primary involved site, followed by spread to peritoneum and tunica vaginalis.
KW - Cytokeratin
KW - Effusion
KW - Electron microscopy
KW - Fine-needle aspiration biopsy
KW - Sarcomatoid-mesothelioma
KW - Vimentin
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U2 - 10.1002/(SICI)1097-0339(199604)14:3<243::AID-DC9>3.0.CO;2-I
DO - 10.1002/(SICI)1097-0339(199604)14:3<243::AID-DC9>3.0.CO;2-I
M3 - Article
C2 - 8732655
AN - SCOPUS:0029877484
VL - 14
SP - 243
EP - 248
JO - Diagnostic Cytopathology
JF - Diagnostic Cytopathology
SN - 8755-1039
IS - 3
ER -