Concordance and clinical significance of uncommon variants of bladder urothelial carcinoma in transurethral resection and radical cystectomy specimens

Tommaso Cai, Daniele Tiscione, Paolo Verze, Giorgio Pomara, Marco Racioppi, Gabriella Nesi, Mattia Barbareschi, Maurizio Brausi, Mauro Gacci, Lorenzo Giuseppe Luciani, Giovanni Liguori, Paolo Gontero, Fabio Campodonico, Alchiede Simonato, Vieri Boddi, Savino M. Di Stasi, Renzo Colombo, Vincenzo Serretta, Giorgio Carmignani, Gianni MalossiniVincenzo Altieri, Marco Carini, Carlo Terrone, Pierfrancesco Bassi, Francesco Montorsi, Vincenzo Ficarra, Cesare Selli, Vincenzo Mirone, Riccardo Bartoletti

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Abstract

Objective To evaluate the concordance and prognostic role of histologic variants of bladder urothelial carcinoma in transurethral resection of bladder tumor (TURBT) and radical cystectomy (RC) specimens.

Methods Clinicopathologic information available at the time of RC and follow-up data from 4110 RC specimens, collected between January 2000 and December 2009 at 17 tertiary referral centers were retrospectively analyzed and evaluated for the presence or absence of uncommon variants of bladder urothelial carcinoma. The presence or absence of uncommon variants of bladder urothelial carcinoma was evaluated on previous TURBT specimens of patients undergoing RC. Cox regression was used to assess the impact of these parameters on cancer-specific survival, and the Kaplan-Meier test for disease-free survival was plotted for survival estimate.

Results Of 4110 patients, 579 were found to have uncommon variants of bladder urothelial carcinoma at RC (14.1%), whereas 266 (6.4%) at TURBT. A lack of agreement about uncommon variants was observed between TURBT and RC specimens in the entire population (P

Conclusion Although the concordance of presence of uncommon histologic variants of urothelial bladder carcinoma between TURBT and RC is low, the presence of uncommon histologic variants of urothelial bladder carcinoma at TURBT is associated with a less favorable clinical outcome.

Original languageEnglish
Pages (from-to)1141-1146
Number of pages6
JournalUrology
Volume84
Issue number5
DOIs
Publication statusPublished - Nov 1 2014

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Cystectomy
Urinary Bladder Neoplasms
Urinary Bladder
Carcinoma
Survival
Kaplan-Meier Estimate
Tertiary Care Centers
Disease-Free Survival
Population
Neoplasms

ASJC Scopus subject areas

  • Urology
  • Medicine(all)

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Concordance and clinical significance of uncommon variants of bladder urothelial carcinoma in transurethral resection and radical cystectomy specimens. / Cai, Tommaso; Tiscione, Daniele; Verze, Paolo; Pomara, Giorgio; Racioppi, Marco; Nesi, Gabriella; Barbareschi, Mattia; Brausi, Maurizio; Gacci, Mauro; Luciani, Lorenzo Giuseppe; Liguori, Giovanni; Gontero, Paolo; Campodonico, Fabio; Simonato, Alchiede; Boddi, Vieri; Di Stasi, Savino M.; Colombo, Renzo; Serretta, Vincenzo; Carmignani, Giorgio; Malossini, Gianni; Altieri, Vincenzo; Carini, Marco; Terrone, Carlo; Bassi, Pierfrancesco; Montorsi, Francesco; Ficarra, Vincenzo; Selli, Cesare; Mirone, Vincenzo; Bartoletti, Riccardo.

In: Urology, Vol. 84, No. 5, 01.11.2014, p. 1141-1146.

Research output: Contribution to journalArticle

Cai, T, Tiscione, D, Verze, P, Pomara, G, Racioppi, M, Nesi, G, Barbareschi, M, Brausi, M, Gacci, M, Luciani, LG, Liguori, G, Gontero, P, Campodonico, F, Simonato, A, Boddi, V, Di Stasi, SM, Colombo, R, Serretta, V, Carmignani, G, Malossini, G, Altieri, V, Carini, M, Terrone, C, Bassi, P, Montorsi, F, Ficarra, V, Selli, C, Mirone, V & Bartoletti, R 2014, 'Concordance and clinical significance of uncommon variants of bladder urothelial carcinoma in transurethral resection and radical cystectomy specimens', Urology, vol. 84, no. 5, pp. 1141-1146. https://doi.org/10.1016/j.urology.2014.06.032
Cai, Tommaso ; Tiscione, Daniele ; Verze, Paolo ; Pomara, Giorgio ; Racioppi, Marco ; Nesi, Gabriella ; Barbareschi, Mattia ; Brausi, Maurizio ; Gacci, Mauro ; Luciani, Lorenzo Giuseppe ; Liguori, Giovanni ; Gontero, Paolo ; Campodonico, Fabio ; Simonato, Alchiede ; Boddi, Vieri ; Di Stasi, Savino M. ; Colombo, Renzo ; Serretta, Vincenzo ; Carmignani, Giorgio ; Malossini, Gianni ; Altieri, Vincenzo ; Carini, Marco ; Terrone, Carlo ; Bassi, Pierfrancesco ; Montorsi, Francesco ; Ficarra, Vincenzo ; Selli, Cesare ; Mirone, Vincenzo ; Bartoletti, Riccardo. / Concordance and clinical significance of uncommon variants of bladder urothelial carcinoma in transurethral resection and radical cystectomy specimens. In: Urology. 2014 ; Vol. 84, No. 5. pp. 1141-1146.
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abstract = "Objective To evaluate the concordance and prognostic role of histologic variants of bladder urothelial carcinoma in transurethral resection of bladder tumor (TURBT) and radical cystectomy (RC) specimens.Methods Clinicopathologic information available at the time of RC and follow-up data from 4110 RC specimens, collected between January 2000 and December 2009 at 17 tertiary referral centers were retrospectively analyzed and evaluated for the presence or absence of uncommon variants of bladder urothelial carcinoma. The presence or absence of uncommon variants of bladder urothelial carcinoma was evaluated on previous TURBT specimens of patients undergoing RC. Cox regression was used to assess the impact of these parameters on cancer-specific survival, and the Kaplan-Meier test for disease-free survival was plotted for survival estimate.Results Of 4110 patients, 579 were found to have uncommon variants of bladder urothelial carcinoma at RC (14.1{\%}), whereas 266 (6.4{\%}) at TURBT. A lack of agreement about uncommon variants was observed between TURBT and RC specimens in the entire population (P Conclusion Although the concordance of presence of uncommon histologic variants of urothelial bladder carcinoma between TURBT and RC is low, the presence of uncommon histologic variants of urothelial bladder carcinoma at TURBT is associated with a less favorable clinical outcome.",
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T1 - Concordance and clinical significance of uncommon variants of bladder urothelial carcinoma in transurethral resection and radical cystectomy specimens

AU - Cai, Tommaso

AU - Tiscione, Daniele

AU - Verze, Paolo

AU - Pomara, Giorgio

AU - Racioppi, Marco

AU - Nesi, Gabriella

AU - Barbareschi, Mattia

AU - Brausi, Maurizio

AU - Gacci, Mauro

AU - Luciani, Lorenzo Giuseppe

AU - Liguori, Giovanni

AU - Gontero, Paolo

AU - Campodonico, Fabio

AU - Simonato, Alchiede

AU - Boddi, Vieri

AU - Di Stasi, Savino M.

AU - Colombo, Renzo

AU - Serretta, Vincenzo

AU - Carmignani, Giorgio

AU - Malossini, Gianni

AU - Altieri, Vincenzo

AU - Carini, Marco

AU - Terrone, Carlo

AU - Bassi, Pierfrancesco

AU - Montorsi, Francesco

AU - Ficarra, Vincenzo

AU - Selli, Cesare

AU - Mirone, Vincenzo

AU - Bartoletti, Riccardo

PY - 2014/11/1

Y1 - 2014/11/1

N2 - Objective To evaluate the concordance and prognostic role of histologic variants of bladder urothelial carcinoma in transurethral resection of bladder tumor (TURBT) and radical cystectomy (RC) specimens.Methods Clinicopathologic information available at the time of RC and follow-up data from 4110 RC specimens, collected between January 2000 and December 2009 at 17 tertiary referral centers were retrospectively analyzed and evaluated for the presence or absence of uncommon variants of bladder urothelial carcinoma. The presence or absence of uncommon variants of bladder urothelial carcinoma was evaluated on previous TURBT specimens of patients undergoing RC. Cox regression was used to assess the impact of these parameters on cancer-specific survival, and the Kaplan-Meier test for disease-free survival was plotted for survival estimate.Results Of 4110 patients, 579 were found to have uncommon variants of bladder urothelial carcinoma at RC (14.1%), whereas 266 (6.4%) at TURBT. A lack of agreement about uncommon variants was observed between TURBT and RC specimens in the entire population (P Conclusion Although the concordance of presence of uncommon histologic variants of urothelial bladder carcinoma between TURBT and RC is low, the presence of uncommon histologic variants of urothelial bladder carcinoma at TURBT is associated with a less favorable clinical outcome.

AB - Objective To evaluate the concordance and prognostic role of histologic variants of bladder urothelial carcinoma in transurethral resection of bladder tumor (TURBT) and radical cystectomy (RC) specimens.Methods Clinicopathologic information available at the time of RC and follow-up data from 4110 RC specimens, collected between January 2000 and December 2009 at 17 tertiary referral centers were retrospectively analyzed and evaluated for the presence or absence of uncommon variants of bladder urothelial carcinoma. The presence or absence of uncommon variants of bladder urothelial carcinoma was evaluated on previous TURBT specimens of patients undergoing RC. Cox regression was used to assess the impact of these parameters on cancer-specific survival, and the Kaplan-Meier test for disease-free survival was plotted for survival estimate.Results Of 4110 patients, 579 were found to have uncommon variants of bladder urothelial carcinoma at RC (14.1%), whereas 266 (6.4%) at TURBT. A lack of agreement about uncommon variants was observed between TURBT and RC specimens in the entire population (P Conclusion Although the concordance of presence of uncommon histologic variants of urothelial bladder carcinoma between TURBT and RC is low, the presence of uncommon histologic variants of urothelial bladder carcinoma at TURBT is associated with a less favorable clinical outcome.

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