TY - JOUR
T1 - Concordance between severity of disease, disability and health-related quality of life in Myasthenia gravis
AU - Raggi, Alberto
AU - Leonardi, Matilde
AU - Antozzi, Carlo
AU - Confalonieri, Paolo
AU - Maggi, Lorenzo
AU - Cornelio, Ferdinando
AU - Mantegazza, Renato
PY - 2010/2
Y1 - 2010/2
N2 - Aim of this study is to verify whether there is concordance between disease's severity, health-related quality of life (HRQoL) and disability in patients with Myasthenia gravis (MG). 102 MG patients were clustered on the basis of HRQoL and disability scores into three groups: low disability and low HRQoL decrement (51 patients), intermediate disability and HRQoL decrement (28 patients), severe disability and high HRQoL decrement (23 patients). Cross tabulation with symmetric measures (Cramer's V and Contingency Coefficient) was used to verify the relationships between disease severity groups, based on the Myasthenia Gravis Foundation of America (MGFA) criteria, and obtained clusters. Results confirm a significant relationship between MG severity groups, HRQoL and disability profiles. In our opinion, HRQoL and disability instruments should be employed in clinical trials to match efficacy of treatments, measured on symptoms' reductions only, with their effects on patients' disability and HRQoL.
AB - Aim of this study is to verify whether there is concordance between disease's severity, health-related quality of life (HRQoL) and disability in patients with Myasthenia gravis (MG). 102 MG patients were clustered on the basis of HRQoL and disability scores into three groups: low disability and low HRQoL decrement (51 patients), intermediate disability and HRQoL decrement (28 patients), severe disability and high HRQoL decrement (23 patients). Cross tabulation with symmetric measures (Cramer's V and Contingency Coefficient) was used to verify the relationships between disease severity groups, based on the Myasthenia Gravis Foundation of America (MGFA) criteria, and obtained clusters. Results confirm a significant relationship between MG severity groups, HRQoL and disability profiles. In our opinion, HRQoL and disability instruments should be employed in clinical trials to match efficacy of treatments, measured on symptoms' reductions only, with their effects on patients' disability and HRQoL.
KW - Disability
KW - Health-related quality of life
KW - International Classification of Functioning, Disability and Health
KW - Myasthenia gravis
KW - WHO-DAS II
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U2 - 10.1007/s10072-009-0167-y
DO - 10.1007/s10072-009-0167-y
M3 - Article
C2 - 19816655
AN - SCOPUS:76449111965
VL - 31
SP - 41
EP - 45
JO - Neurological Sciences
JF - Neurological Sciences
SN - 1590-1874
IS - 1
ER -