Concordance of angiographic and electrocardiographic indexes of microvascular obstruction: Myocardial haemorrhage role

Giampaolo Niccoli, Nicola Cosentino, Cristina Spaziani, Valentina Loria, Francesco Fracassi, Marco Roberto, Camilla Calvieri, Antonella Lombardo, Luigi Natale, Carmela Napolitano, Alessandro Mandurinoa, Francesco Burzotta, Antonio Maria Leone, Italo Porto, Carlo Trani, Lorenzo Bonomo, Filippo Crea

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Angiographic and electrocardiographic (ECG) indexes of microvascular obstruction (MVO) have been described. We aimed at assessing by cardiac magnetic resonance (CMR) anatomical features underlying concordance between them. METHODS: Forty-one patients were enrolled. Patients presented with neither angiographic nor ECG indexes of MVO (without MVO) (44%), with either angiographic or ECG indexes of MVO (discordant with MVO) (22%) or with both angiographic and ECG indexes of MVO (concordant with MVO) (34%). All patients underwent in-hospital CMR. Echocardiographic data obtained after 6 months were compared with those obtained in hospital. RESULTS: Concordant patients with MVO had larger infarct size, lower myocardial salvage index and higher rate of myocardial haemorrhage (all assessed by CMR) [33% (25-41%), 15% (10-29%) and 88%, respectively] as compared with patients without MVO [12% (9-16%), 66% (52-79%) and 0%; Bonferroni-adjusted P <0.001, Bonferroni-adjusted P <0.001 and P <0.001, respectively], or with discordant ones [25% (21-39%), 35% (20-48%) and 7%; Bonferroni-adjusted P = 0.03, Bonferroni-adjusted P = 0.002 and P = 0.04, respectively]. After 6 months, ejection fraction significantly decreased in concordant patients with MVO (P <0.001) without significant changes in the other groups. CONCLUSIONS: Concordance of angiographic and ECG indexes of MVO reflects more severe myocardial damage translating into unfavourable left ventricular remodelling.

Original languageEnglish
JournalJournal of Cardiovascular Medicine
DOIs
Publication statusAccepted/In press - Jul 31 2014

Fingerprint

Hemorrhage
Magnetic Resonance Spectroscopy
Ventricular Remodeling

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Concordance of angiographic and electrocardiographic indexes of microvascular obstruction : Myocardial haemorrhage role. / Niccoli, Giampaolo; Cosentino, Nicola; Spaziani, Cristina; Loria, Valentina; Fracassi, Francesco; Roberto, Marco; Calvieri, Camilla; Lombardo, Antonella; Natale, Luigi; Napolitano, Carmela; Mandurinoa, Alessandro; Burzotta, Francesco; Leone, Antonio Maria; Porto, Italo; Trani, Carlo; Bonomo, Lorenzo; Crea, Filippo.

In: Journal of Cardiovascular Medicine, 31.07.2014.

Research output: Contribution to journalArticle

Niccoli, G, Cosentino, N, Spaziani, C, Loria, V, Fracassi, F, Roberto, M, Calvieri, C, Lombardo, A, Natale, L, Napolitano, C, Mandurinoa, A, Burzotta, F, Leone, AM, Porto, I, Trani, C, Bonomo, L & Crea, F 2014, 'Concordance of angiographic and electrocardiographic indexes of microvascular obstruction: Myocardial haemorrhage role', Journal of Cardiovascular Medicine. https://doi.org/10.2459/JCM.0000000000000178
Niccoli, Giampaolo ; Cosentino, Nicola ; Spaziani, Cristina ; Loria, Valentina ; Fracassi, Francesco ; Roberto, Marco ; Calvieri, Camilla ; Lombardo, Antonella ; Natale, Luigi ; Napolitano, Carmela ; Mandurinoa, Alessandro ; Burzotta, Francesco ; Leone, Antonio Maria ; Porto, Italo ; Trani, Carlo ; Bonomo, Lorenzo ; Crea, Filippo. / Concordance of angiographic and electrocardiographic indexes of microvascular obstruction : Myocardial haemorrhage role. In: Journal of Cardiovascular Medicine. 2014.
@article{9e3c9168812743c194fc02a8ae83f540,
title = "Concordance of angiographic and electrocardiographic indexes of microvascular obstruction: Myocardial haemorrhage role",
abstract = "BACKGROUND: Angiographic and electrocardiographic (ECG) indexes of microvascular obstruction (MVO) have been described. We aimed at assessing by cardiac magnetic resonance (CMR) anatomical features underlying concordance between them. METHODS: Forty-one patients were enrolled. Patients presented with neither angiographic nor ECG indexes of MVO (without MVO) (44{\%}), with either angiographic or ECG indexes of MVO (discordant with MVO) (22{\%}) or with both angiographic and ECG indexes of MVO (concordant with MVO) (34{\%}). All patients underwent in-hospital CMR. Echocardiographic data obtained after 6 months were compared with those obtained in hospital. RESULTS: Concordant patients with MVO had larger infarct size, lower myocardial salvage index and higher rate of myocardial haemorrhage (all assessed by CMR) [33{\%} (25-41{\%}), 15{\%} (10-29{\%}) and 88{\%}, respectively] as compared with patients without MVO [12{\%} (9-16{\%}), 66{\%} (52-79{\%}) and 0{\%}; Bonferroni-adjusted P <0.001, Bonferroni-adjusted P <0.001 and P <0.001, respectively], or with discordant ones [25{\%} (21-39{\%}), 35{\%} (20-48{\%}) and 7{\%}; Bonferroni-adjusted P = 0.03, Bonferroni-adjusted P = 0.002 and P = 0.04, respectively]. After 6 months, ejection fraction significantly decreased in concordant patients with MVO (P <0.001) without significant changes in the other groups. CONCLUSIONS: Concordance of angiographic and ECG indexes of MVO reflects more severe myocardial damage translating into unfavourable left ventricular remodelling.",
author = "Giampaolo Niccoli and Nicola Cosentino and Cristina Spaziani and Valentina Loria and Francesco Fracassi and Marco Roberto and Camilla Calvieri and Antonella Lombardo and Luigi Natale and Carmela Napolitano and Alessandro Mandurinoa and Francesco Burzotta and Leone, {Antonio Maria} and Italo Porto and Carlo Trani and Lorenzo Bonomo and Filippo Crea",
year = "2014",
month = "7",
day = "31",
doi = "10.2459/JCM.0000000000000178",
language = "English",
journal = "Journal of Cardiovascular Medicine",
issn = "1558-2027",
publisher = "Lippincott Williams and Wilkins",

}

TY - JOUR

T1 - Concordance of angiographic and electrocardiographic indexes of microvascular obstruction

T2 - Myocardial haemorrhage role

AU - Niccoli, Giampaolo

AU - Cosentino, Nicola

AU - Spaziani, Cristina

AU - Loria, Valentina

AU - Fracassi, Francesco

AU - Roberto, Marco

AU - Calvieri, Camilla

AU - Lombardo, Antonella

AU - Natale, Luigi

AU - Napolitano, Carmela

AU - Mandurinoa, Alessandro

AU - Burzotta, Francesco

AU - Leone, Antonio Maria

AU - Porto, Italo

AU - Trani, Carlo

AU - Bonomo, Lorenzo

AU - Crea, Filippo

PY - 2014/7/31

Y1 - 2014/7/31

N2 - BACKGROUND: Angiographic and electrocardiographic (ECG) indexes of microvascular obstruction (MVO) have been described. We aimed at assessing by cardiac magnetic resonance (CMR) anatomical features underlying concordance between them. METHODS: Forty-one patients were enrolled. Patients presented with neither angiographic nor ECG indexes of MVO (without MVO) (44%), with either angiographic or ECG indexes of MVO (discordant with MVO) (22%) or with both angiographic and ECG indexes of MVO (concordant with MVO) (34%). All patients underwent in-hospital CMR. Echocardiographic data obtained after 6 months were compared with those obtained in hospital. RESULTS: Concordant patients with MVO had larger infarct size, lower myocardial salvage index and higher rate of myocardial haemorrhage (all assessed by CMR) [33% (25-41%), 15% (10-29%) and 88%, respectively] as compared with patients without MVO [12% (9-16%), 66% (52-79%) and 0%; Bonferroni-adjusted P <0.001, Bonferroni-adjusted P <0.001 and P <0.001, respectively], or with discordant ones [25% (21-39%), 35% (20-48%) and 7%; Bonferroni-adjusted P = 0.03, Bonferroni-adjusted P = 0.002 and P = 0.04, respectively]. After 6 months, ejection fraction significantly decreased in concordant patients with MVO (P <0.001) without significant changes in the other groups. CONCLUSIONS: Concordance of angiographic and ECG indexes of MVO reflects more severe myocardial damage translating into unfavourable left ventricular remodelling.

AB - BACKGROUND: Angiographic and electrocardiographic (ECG) indexes of microvascular obstruction (MVO) have been described. We aimed at assessing by cardiac magnetic resonance (CMR) anatomical features underlying concordance between them. METHODS: Forty-one patients were enrolled. Patients presented with neither angiographic nor ECG indexes of MVO (without MVO) (44%), with either angiographic or ECG indexes of MVO (discordant with MVO) (22%) or with both angiographic and ECG indexes of MVO (concordant with MVO) (34%). All patients underwent in-hospital CMR. Echocardiographic data obtained after 6 months were compared with those obtained in hospital. RESULTS: Concordant patients with MVO had larger infarct size, lower myocardial salvage index and higher rate of myocardial haemorrhage (all assessed by CMR) [33% (25-41%), 15% (10-29%) and 88%, respectively] as compared with patients without MVO [12% (9-16%), 66% (52-79%) and 0%; Bonferroni-adjusted P <0.001, Bonferroni-adjusted P <0.001 and P <0.001, respectively], or with discordant ones [25% (21-39%), 35% (20-48%) and 7%; Bonferroni-adjusted P = 0.03, Bonferroni-adjusted P = 0.002 and P = 0.04, respectively]. After 6 months, ejection fraction significantly decreased in concordant patients with MVO (P <0.001) without significant changes in the other groups. CONCLUSIONS: Concordance of angiographic and ECG indexes of MVO reflects more severe myocardial damage translating into unfavourable left ventricular remodelling.

UR - http://www.scopus.com/inward/record.url?scp=84905298741&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84905298741&partnerID=8YFLogxK

U2 - 10.2459/JCM.0000000000000178

DO - 10.2459/JCM.0000000000000178

M3 - Article

AN - SCOPUS:84905298741

JO - Journal of Cardiovascular Medicine

JF - Journal of Cardiovascular Medicine

SN - 1558-2027

ER -