Concurrent boost radiotherapy as preoperative treatment for locally advanced rectal carcinoma: A new beam arrangement

Carlo Capirci, Francesca Valvo, Simonetta Salviato, Marcello Gava, Giovanni Mandoliti, Anna Di Russo, Kevin Tapia Torrez, Cesare Polico

Research output: Contribution to journalArticle

Abstract

Purpose: To describe a new beam arrangement for preoperative concurrent boost radiotherapy in locally advanced rectal carcinoma. Material and methods: Three different volumes, ie posterior pelvis, total mesorectal space, and gross tumor volume plus 2 cm, are selected to receive radiation doses of 47 Gy, 51 Gy, and 54 Gy, respectively, in 24 fractions. There are two prerequisites for the use of such a radiotherapy schedule: complete displacement of the small bowel outside the boost volume, and horizontal positioning of the rectal long axis. Both conditions can be attained by patient positioning on a new device, the "Up-Down Table" (UDT). The dose gradient between the three volumes is realized with two daily arc rotation fields with an isocenter that is different from the three additional multileaf collimator pelvic fields (postero-anterior + 2 laterolateral). Results: The treatment data are reported according to the ICRU 62 criteria. A comparison was made between concurrent arc rotation and concomitant static boost techniques. Conclusion: The new beam arrangement, with the use of the UDT, allows to administer different radiation doses to three volumes with different tumor cell density in order to obtain the same probability of local response in all target volumes without increasing the toxicity.

Original languageEnglish
Pages (from-to)325-330
Number of pages6
JournalTumori
Volume88
Issue number4
Publication statusPublished - Jul 2002

Fingerprint

Radiotherapy
Radiation
Carcinoma
Patient Positioning
Tumor Burden
Pelvis
Appointments and Schedules
Cell Count
Equipment and Supplies
Therapeutics
Neoplasms

Keywords

  • Concurrent boost radiotherapy
  • Preoperative radiotherapy
  • Rectal cancer

ASJC Scopus subject areas

  • Cancer Research

Cite this

Capirci, C., Valvo, F., Salviato, S., Gava, M., Mandoliti, G., Di Russo, A., ... Polico, C. (2002). Concurrent boost radiotherapy as preoperative treatment for locally advanced rectal carcinoma: A new beam arrangement. Tumori, 88(4), 325-330.

Concurrent boost radiotherapy as preoperative treatment for locally advanced rectal carcinoma : A new beam arrangement. / Capirci, Carlo; Valvo, Francesca; Salviato, Simonetta; Gava, Marcello; Mandoliti, Giovanni; Di Russo, Anna; Torrez, Kevin Tapia; Polico, Cesare.

In: Tumori, Vol. 88, No. 4, 07.2002, p. 325-330.

Research output: Contribution to journalArticle

Capirci, C, Valvo, F, Salviato, S, Gava, M, Mandoliti, G, Di Russo, A, Torrez, KT & Polico, C 2002, 'Concurrent boost radiotherapy as preoperative treatment for locally advanced rectal carcinoma: A new beam arrangement', Tumori, vol. 88, no. 4, pp. 325-330.
Capirci, Carlo ; Valvo, Francesca ; Salviato, Simonetta ; Gava, Marcello ; Mandoliti, Giovanni ; Di Russo, Anna ; Torrez, Kevin Tapia ; Polico, Cesare. / Concurrent boost radiotherapy as preoperative treatment for locally advanced rectal carcinoma : A new beam arrangement. In: Tumori. 2002 ; Vol. 88, No. 4. pp. 325-330.
@article{50b0d63cb2b54533b0965fa3d3a29a80,
title = "Concurrent boost radiotherapy as preoperative treatment for locally advanced rectal carcinoma: A new beam arrangement",
abstract = "Purpose: To describe a new beam arrangement for preoperative concurrent boost radiotherapy in locally advanced rectal carcinoma. Material and methods: Three different volumes, ie posterior pelvis, total mesorectal space, and gross tumor volume plus 2 cm, are selected to receive radiation doses of 47 Gy, 51 Gy, and 54 Gy, respectively, in 24 fractions. There are two prerequisites for the use of such a radiotherapy schedule: complete displacement of the small bowel outside the boost volume, and horizontal positioning of the rectal long axis. Both conditions can be attained by patient positioning on a new device, the {"}Up-Down Table{"} (UDT). The dose gradient between the three volumes is realized with two daily arc rotation fields with an isocenter that is different from the three additional multileaf collimator pelvic fields (postero-anterior + 2 laterolateral). Results: The treatment data are reported according to the ICRU 62 criteria. A comparison was made between concurrent arc rotation and concomitant static boost techniques. Conclusion: The new beam arrangement, with the use of the UDT, allows to administer different radiation doses to three volumes with different tumor cell density in order to obtain the same probability of local response in all target volumes without increasing the toxicity.",
keywords = "Concurrent boost radiotherapy, Preoperative radiotherapy, Rectal cancer",
author = "Carlo Capirci and Francesca Valvo and Simonetta Salviato and Marcello Gava and Giovanni Mandoliti and {Di Russo}, Anna and Torrez, {Kevin Tapia} and Cesare Polico",
year = "2002",
month = "7",
language = "English",
volume = "88",
pages = "325--330",
journal = "Tumori",
issn = "0300-8916",
publisher = "SAGE Publications Ltd",
number = "4",

}

TY - JOUR

T1 - Concurrent boost radiotherapy as preoperative treatment for locally advanced rectal carcinoma

T2 - A new beam arrangement

AU - Capirci, Carlo

AU - Valvo, Francesca

AU - Salviato, Simonetta

AU - Gava, Marcello

AU - Mandoliti, Giovanni

AU - Di Russo, Anna

AU - Torrez, Kevin Tapia

AU - Polico, Cesare

PY - 2002/7

Y1 - 2002/7

N2 - Purpose: To describe a new beam arrangement for preoperative concurrent boost radiotherapy in locally advanced rectal carcinoma. Material and methods: Three different volumes, ie posterior pelvis, total mesorectal space, and gross tumor volume plus 2 cm, are selected to receive radiation doses of 47 Gy, 51 Gy, and 54 Gy, respectively, in 24 fractions. There are two prerequisites for the use of such a radiotherapy schedule: complete displacement of the small bowel outside the boost volume, and horizontal positioning of the rectal long axis. Both conditions can be attained by patient positioning on a new device, the "Up-Down Table" (UDT). The dose gradient between the three volumes is realized with two daily arc rotation fields with an isocenter that is different from the three additional multileaf collimator pelvic fields (postero-anterior + 2 laterolateral). Results: The treatment data are reported according to the ICRU 62 criteria. A comparison was made between concurrent arc rotation and concomitant static boost techniques. Conclusion: The new beam arrangement, with the use of the UDT, allows to administer different radiation doses to three volumes with different tumor cell density in order to obtain the same probability of local response in all target volumes without increasing the toxicity.

AB - Purpose: To describe a new beam arrangement for preoperative concurrent boost radiotherapy in locally advanced rectal carcinoma. Material and methods: Three different volumes, ie posterior pelvis, total mesorectal space, and gross tumor volume plus 2 cm, are selected to receive radiation doses of 47 Gy, 51 Gy, and 54 Gy, respectively, in 24 fractions. There are two prerequisites for the use of such a radiotherapy schedule: complete displacement of the small bowel outside the boost volume, and horizontal positioning of the rectal long axis. Both conditions can be attained by patient positioning on a new device, the "Up-Down Table" (UDT). The dose gradient between the three volumes is realized with two daily arc rotation fields with an isocenter that is different from the three additional multileaf collimator pelvic fields (postero-anterior + 2 laterolateral). Results: The treatment data are reported according to the ICRU 62 criteria. A comparison was made between concurrent arc rotation and concomitant static boost techniques. Conclusion: The new beam arrangement, with the use of the UDT, allows to administer different radiation doses to three volumes with different tumor cell density in order to obtain the same probability of local response in all target volumes without increasing the toxicity.

KW - Concurrent boost radiotherapy

KW - Preoperative radiotherapy

KW - Rectal cancer

UR - http://www.scopus.com/inward/record.url?scp=0036658220&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036658220&partnerID=8YFLogxK

M3 - Article

C2 - 12400985

AN - SCOPUS:0036658220

VL - 88

SP - 325

EP - 330

JO - Tumori

JF - Tumori

SN - 0300-8916

IS - 4

ER -