Concurrent comparison of the measurement properties of generic and disease-specific questionnaires in obese inpatients

A. Sartorio, F. Agosti, A. De Col, G. Castelnuovo, G. M. Manzoni, E. Molinari, F. M. Impellizzeri

Research output: Contribution to journalArticlepeer-review


Background: The concurrent comparison of questionnaires assessing health-related quality of life in the same population is necessary for better appreciating their performance and to select the best instrument for a given purpose (e.g. clinical trials and observational studies). Aim: The aim of this study was to compare the measurement properties of two disease-specific and generic questionnaires: the Obesity-related Well-Being (ORWELL97), the Obesity-Related Disability test (TSD-OC), the Euro- QoL, and the World Health Organization Quality of Life questionnaire. Materials/subjects: Two-hundreds and forty-nine obese inpatients [age 47 (standard deviation, SD 15) years, body mass index 44.4 (SD 5.2) kg/m2, 69% female] completed the four questionnaires before and after a 3-week multidisciplinary weight reduction program. Standard measurement properties were calculated and compared. Results: Intra-class correlation coefficient ranged from 0.73 to 0.90 for most of the instruments and subscales. The standard error of measurement ranged from 9 to 21% for the generic instruments, and from 9 to 44% for the specific questionnaires. Missing data and ceiling effects were found for TSD-OC. Responsiveness was similar for all the instruments. The correlations between the change scores of the instruments were small (

Original languageEnglish
Pages (from-to)31-42
Number of pages12
JournalJournal of Endocrinological Investigation
Issue number1
Publication statusPublished - 2014


  • Measurement properties
  • Obesity
  • Quality of life
  • Questionnaires

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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